Select the drug indication to add to your list

Leukemias, lymphomas, and other hematologic cancers
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:


Generic Name and Formulations:
Idelalisib 100mg, 150mg; tabs.

Gilead Sciences, Inc.

Therapeutic Use:

Indications for ZYDELIG:

Relapsed chronic lymphocytic leukemia (CLL), in combination with rituximab, in patients for whom rituximab alone would be considered appropriate due to other co-morbidities. Relapsed follicular B-cell non-Hodgkin lymphoma (FL) in patients who have received at least 2 prior systemic therapies. Relapsed small lymphocytic lymphoma (SLL) in patients who have received at least 2 prior systemic therapies.

Limitations Of use:

Not recommended for first-line treatment of CLL, FL, SLL, or in combination with bendamustine and/or rituximab for FL.


Swallow whole. ≥18yrs: initially 150mg twice daily (max); continue until disease progression or unacceptable toxicity. Dose modifications: see full labeling.


<18yrs: not established.


History of serious allergic reactions including anaphylaxis and toxic epidermal necrolysis.

Boxed Warning:

Fatal and serious toxicities: hepatic, severe diarrhea, colitis, pneumonitis, infections, and intestinal perforation.


Risk of fatal/serious hepatotoxicity: monitor ALT/AST every 2 weeks for the first 3 months, every 4 weeks for the next 3 months, then every 1–3 months thereafter; if ALT/AST >3xULN, monitor weekly until resolved; if ALT/AST >5xULN, withhold and continue monitoring weekly until resolved; if ALT/AST >20xULN or bilirubin >10xULN, discontinue permanently. Monitor for diarrhea or colitis; withhold if severe or hospitalization; discontinue permanently if life-threatening. Risk of fatal/serious pneumonitis; monitor for pulmonary symptoms or a decline by >5% in oxygen saturation; if diagnosed, treat and discontinue permanently. Risk of fatal/serious infections; monitor for signs/symptoms and interrupt if Grade ≥3. Treat infections before starting. Provide Pneumocystis jirovecii pneumonia (PJP) prophylaxis during treatment; interrupt if PJP infection is suspected and permanently discontinue if confirmed. Monitor patients with history of CMV infection or (+) baseline CMV serology; interrupt if CMV PCR (+) until resolved; if resumed, monitor for reactivation at least monthly. Risk of fatal/serious intestinal perforation; discontinue permanently if occurs. Monitor for severe cutaneous or serious allergic reactions; discontinue if occur. Monitor CBCs at least every 2 weeks for the first 6 months, and at least weekly if neutrophils <1.0Gi/L. Hepatic impairment; monitor. Embryo-fetal toxicity. Pregnancy: exclude status prior to initiation. Use effective contraception during and for at least 1 month (females) or 3 months (males w. female partners) after last dose. Nursing mothers: not recommended (during and for 1 month after last dose).

Pharmacological Class:

Phosphatidylinositol 3-kinase inhibitor.


Avoid concomitant drugs that can cause hepatotoxicity or diarrhea. May be potentiated by strong CYP3A inhibitors (eg, ketoconazole); use alternatives or monitor frequently for idelalisib toxicity. May be antagonized by strong CYP3A inducers (eg, rifampin); avoid. May potentiate CYP3A substrates (eg, oral midazolam); avoid.

Adverse Reactions:

Diarrhea, pyrexia, fatigue, nausea, cough, pneumonia, abdominal pain, chills, rash, neutropenia, ALT/AST elevations.



How Supplied:


Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs