Study finds $1 test using gold nanoparticles outperforms PSA screen for prostate cancer

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Study finds $1 test using gold nanoparticles outperforms PSA screen for prostate cancer
Study finds $1 test using gold nanoparticles outperforms PSA screen for prostate cancer

A test that costs less than a $1 and yields results in minutes has been shown in recently published studies to be more sensitive and more exact than the current standard test for early stage prostate cancer. These findings were published in ACS Applied Materials & Interfaces (2015; 10.1021/acsami.5b00371).

The simple test developed by University of Central Florida scientist Qun "Treen" Huo, PhD, holds the promise of earlier detection of one of the deadliest cancers among men. It would also reduce the number of unnecessary and invasive biopsies stemming from the less precise prostate-specific antigen (PSA) test that is now used.

"It's fantastic," said Inoel Rivera, MD, a urologic oncologist at Florida Hospital Cancer Institute, which collaborated with Huo on the recent pilot studies. "It's a simple test. It's much better than the test we have right now, which is the PSA, and it's cost-effective."

When a cancerous tumor begins to develop, the body mobilizes to produce antibodies. Huo's test detects that immune response using gold nanoparticles approximately 10,000 times smaller than a freckle.

When a few drops of blood serum from a finger prick are mixed with the gold nanoparticles, certain cancer biomarkers cling to the surface of the tiny particles, increasing their size and causing them to clump together.

Among researchers, gold nanoparticles are known for their extraordinary efficiency at absorbing and scattering light. Huo and her team at UCF's NanoScience Technology Center developed a technique known as nanoparticle-enabled dynamic light scattering assay (NanoDLSay) to measure the size of the particles by analyzing the light they throw off. That size reveals whether a patient has prostate cancer and how advanced it may be.

Although it uses gold, the test is inexpensive. A small bottle of nanoparticles suspended in water costs about $250, and contains enough for approximately 2,500 tests.

"What's different and unique about our technique is it's a very simple process, and the material required for the test is less than $1," Huo said. "And because it's low-cost, we're hoping most people can have this test in their doctor's office. If we can catch this cancer in its early stages, the impact is going to be big."

After lung cancer, prostate cancer is the second-leading killer cancer among men, with more than 240,000 new diagnoses and 28,000 deaths every year. The most commonly used screening tool is the PSA, but it produces so many false-positive results—leading to painful biopsies and extreme treatments—that one of its discoverers recently called it "hardly more effective than a coin toss."

Pilot studies found Huo's technique is significantly more exact. The test determines with 90% to 95% confidence that the result is not false-positive. When it comes to false-negatives, there is 50% confidence. That is not ideal, but still significantly higher than the PSA's 20%, and Huo is working to improve that number.

"Potentially, we could have a universal screening test for cancer," Huo said. "Our vision is to develop an array of blood tests for early detection and diagnosis of all major cancer types, and these blood tests are all based on the same technique and same procedure."

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