Measuring hepatic function can be used to plan treatment for liver cancer patients

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Monitoring the hepatic function of unresectable liver cancer patients provides vital information that could guide more customized treatment plans and reduce risks of liver injury. A recent study measured hepatic function with 99mTc-labeled iminodiacetic acid (HIDA) via single-photon emission computed tomography (SPECT) prior to and during radiation therapy.

This study included 14 patients who had unresectable intrahepatic cancers and were treated with 3-D conformal radiation therapy (3-D CRT), intensity modulated radiation therapy (IMRT), or stereotactic body radiation therapy (SBRT) at a median dose of 52 Gy.

The patients underwent HIDA SPECT scanning prior to radiation therapy, after delivery of 50% to 60% of the planned doses and 1 month after completion of radiation therapy. In addition, indocyanine green tests, which are a measure of overall liver function, were performed within 1 day of each SPECT scan. The 27 dynamic HIDA SPECT volumes were acquired over a 60-minute period after the administration of 10 mCi 99mTc-labeled HIDA on a SPECT/CT scanner.

Measuring the regional liver function prior to radiation therapy allows assessment of the precondition of the patient's liver function. Evaluating the change of the regional liver function during the mid-course of radiation therapy indicates the response of the individual patient's liver to radiation doses. Combining the planned radiation doses with the regional liver function assessment and reassessment, investigators developed a model to predict the regional liver function after radiation therapy. This information is vital to providing patients with the highest radiation doses for better tumor control, while minimizing the risk for each patient.

“Through this assessment method, patients could potentially receive more treatment doses tailored to meet their needs, based on their liver function,” said lead study author Hesheng Wang, PhD, of the University of Michigan in Ann Arbor, Michigan. “The physiological adaptation of radiation therapy based upon individual response assessment is a valuable new paradigm worth additional testing.”

This research was presented at the 2013 Cancer Imaging and Radiation Therapy Symposium in Orlando, Florida, which is sponsored by the American Society for Radiation Oncology and the Radiological Society of North America.

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