Bone marrow produces glioma treatment

Share this content:

Genetic material secreted by bone marrow cells was used to reduce glioma tumor volume in a recent study.

The project centered on the use of exosomes culled from bone marrow stromal cells (MSCs). As explained in a statement from Henry Ford Health System in Detroit, Michigan, where the research was conducted, exosomes are microscopic “lipid bubbles” that carry RNA.

Exosomes containing the microRNA (miR) 146b, which [previously had been found to have a strong effect on glioma tumor cells, were injected into glioma tumor cells that had been implanted into laboratory rats 5 days earlier. Glioma is the most common type of malignant brain tumor, and is associated with a poor prognosis for survival.

When the gliomas were measured 5 days after exosome injection, tumor volume had been significantly reduced.

“Our data suggest that miR-146b elicits an antitumor effect in the rat brain, and that MSCs can be used as a ‘factory' to generate exosomes genetically altered to contain miR-146b to effectively treat tumors,” noted investigator Michael Chopp, PhD, in the Henry Ford statement.

Chopp, who is the scientific director of the Henry Ford Neuroscience Institute and vice chairman of the Department of Neurology at Henry Ford Hospital, and his fellow researchers detailed their findings in Cancer Letters.

You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs