Toxicity Similar, But Overall Survival Poor in Cetuximab vs Cisplatin for HPV-Positive Oropharyngeal Cancer
In a randomized phase 3 trial, researchers sought to determine if cetuximab-based chemoradiotherapy could be a less-toxic alternative to cisplatin-based chemoradiotherapy in patients with HPV-positive oropharyngeal cancer.
This retrospective analysis determined the effect of Doxil vs Lipodox brands of doxorubicin, used for the treatment of recurrent or refractory ovarian cancer.
FDA grants approval to tagraxofusp-erzs (Elzonris), a first treatment for blastic plasmacytoid dentritic cell neoplasm and the first therapy to target CD123.
A data analysis revealed a genetic predictor of relapse for pediatric patients with ALL.
Researchers determined the 5-year overall and disease-free survival for patients with CSCC of the head and neck who received adjuvant radiation therapy.
Researchers sought to determine the association between chemotherapy, particularly platinum-based agents, and increased risk of tMDS/AML.
A decision-analysis was used to determine which treatment of BR/LA PDAC was more efficacious and more cost-effective: neoadjuvant FOLFIRINOX vs surgery with GEM/CAPE vs surgery with gemcitabine.
Researchers sought to determine the effect of radical prostatectomy vs watchful waiting on life expectancy in men with prostate cancer.
All-Grade AE Profiles Better Measure of Quality of Life in Metastatic Castration-Naïve Prostate Cancer
A study evaluating patient vs clinician reports of adverse events reveals which measures provide a more accurate perspective on patient quality of life.
After implementing a web-based tool for patients with cancer, researchers surveyed healthcare providers involved in the pilot project regarding their thoughts and experiences with the project.
Researchers present results of an interim analysis of a study on the prevalence of advanced colorectal neoplasia among survivors of Hodgkin lymphoma.
No Benefit Achieved With Cytoreductive Therapy for Essential Thrombocythemia With Nonhigh Risk of Thrombosis
A study with more than 2000 patient-years follow-up, researchers found cytoreductive therapy was not as effective in patients with ET who have lower risk for thrombosis.
In developing a biosimilar to trastuzumab, researchers discovered a downward shift in ADCC in lots of the reference drug suggesting the 2 drugs may not be completely identical.
Researchers evaluated the effectiveness of a smartphone app in encouraging breast cancer survivors to meet their posttreatment exercise goals.
Researchers assessed self-reports of chronic systemic symptoms experienced by head and neck cancer survivors at least 1 year posttreatment.
Intravenous immunoglobulin G with plasma from fewer blood donations provides sufficient therapeutic effect for pediatric patients with ITP.
A clinical trial demonstrates that apixaban effectively decreases risk of VTE in patients with cancer; however, risk of major bleeding episodes may be higher.
Researchers sought to determine the quality and accuracy of information on prostate cancer disseminated through YouTube videos.
A survey-based study revealed that women with greater concerns regarding tamoxifen and medicine in general are less likely to take the drug as a preventive measure.
In this study, researchers sought to determine the preferred treatment attributes of patients with RRMM, and which they are willing to let go in trade-offs.
Researchers investigating genotype-phenotype relationships found that clinical manifestations of some diseases do not match the incidence of genetic variants that predict disease risk.
A retrospective study identifies prognoses and risk factors for SCC among solid organ transplant recipients.
Researchers within a health care system investigated the use of advance care planning among elderly patients undergoing surgery.
A secondary analysis of data from the CONVERT trial compared survival outcomes after chemoradiotherapy for patients with stage I-II vs patients with stage III disease.
Using a gene expression-based identifier, researchers found a method for discerning patients with DLBCL who may benefit from nonstandard therapies.
This retrospective study sought to determine if BIS could detect lymphedema in breast cancer survivors after surgery earlier than other volumetric techniques.
Clinician Interaction Scored High, Some Discussion Topics Did Not in Patient Assessment of Quality of Care
In a survey of patients' perceptions, doctor/nurse interactions were rated high; however, some specific topics for discussion were not rated as high.
A review of data collected from an electronic health record database identified the adverse effects most likely to result in avoidable hospitalizations among patients receiving HECs for breast cancer.
Researchers assessed shoulder mobility after breast-conserving surgery, comparing results after node-negative and node-positive treatment protocols and healthy controls.
The construct from Allogene has been engineered to avoid the serious immune-related complications linked to allogeneic transplantation.
Early results of phase 1, dose-escalation trial demonstrate efficacy and safety of P-BCMA-101 CAR-T cell therapy in patients with R/R MM.
A single-center study demonstrated that induction therapy can influence OS and DFS in patients with intermediate or high NCCN risk acute myeloid leukemia.
A retrospective and prospective study of Italian adult patients with CML investigated the potential for childbearing and outcomes in this patient population.
Researchers sought to determine if the complementary practice could prevent CIPN in patients receiving adjuvant chemotherapy for breast cancer.
Study findings measure quality of life for pregnant patients with breast cancer and reveals the effectiveness of disease-specific assessment tools.
Study measures the usefulness of systemic imaging in early-stage breast cancer.
Few women aged 70 and older with breast cancer undergo postmastectomy breast reconstruction due to potential complications; however, these patients are not less likely to have good outcomes.
Researchers sought to determine how subjective measures of CIPN correlated with objective measures of CIPN.
Pilot study sought to determine risk of breast cancer among African American women veterans.
A worldwide survey reveals that despite similar perceptions on symptom burden of ITP, patients and physicians do not agree on the effect of fatigue on quality of life.
PFS, OS Improved With Sequential Rituximab/Bendamustine, Rituximab/Cytarabine in Untreated Mantle Cell Lymphoma
Two simultaneous studies demonstrate improved progression-free survival and overall survival in patients with uMCL who receive induction therapy with RB/RC followed by ASCT.
Phlebotomy and hydroxyurea tied to improved survival, lower risk for thrombosis in older patients.
Stringent CR criteria may not predict clinical outcomes for patients with multiple myeloma.
US FDA recently approved rituximab biosimilar as monotherapy and in combination with chemotherapy.
Checkpoint-based therapies may sensitize patients to subsequent therapies.
Randomized clinical trial showed significant improvement in overall survival with glasdegib.
A retrospective review identified a subset of patients with squamous cell carcinoma of the anal canal with distant metastases who respond to extended-field chemoradiation.
Researchers conducted a study to gauge the potential acceptance of sensored medication devices among patients with multiple myeloma.
Using focus groups, researchers evaluated patient-reported psychosocial consequences of lung cancer to determine if a lung cancer-specific distress screening instrument would benefit these patients.
Clinicians report on the challenges of managing rasburicase-induced G6PD deficiency in patients undergoing treatment for tumor lysis syndrome.
A review of studies on clinician education in palliative care identified themes for core palliative care competencies for pediatric oncologists.
Researchers investigated the safety and efficacy of combination therapy with azacytidine and nivolumab for relapsed/refractory AML.
Higher rates of adverse events observed for immune checkpoint inhibitors in real-world settings, compared to clinical trials.
Using data from the phase 3 trial CALGB 40101, researchers determined the risk for chemotherapy-induced neuropathy among patients with early-stage breast cancer receiving adjuvant paclitaxel weekly or biweekly.
A review is presented of adverse events common with 5 oral chemotherapy drugs used to treat renal cell carcinoma.
In men, overweight and even higher normal weight is associated with an increased risk of future pancreatic cancer.
Postchemotherapy hospitalizations and costs are higher for patients receiving highly emetogenic chemotherapy with no prophylaxis treatment.
Artificial intelligence and mobile technology combined in a smartphone app demonstrated an ability to accurately measure and respond to urgency of patients' pain.
Patients with nonresectable tumors randomized to palliative rehabilitation also chose to participate in individual consultations and a group program with physical activity.
Changes in pain management due to parenteral opioid shortage has initial negative effect, then stabilizes.
Proliferative state lead to rare case of TLS and renal failure in a patient with MM receiving elotuzumab.
Real-World Prevalence of AEs With Immune Checkpoint Inhibitors for NSCLC Higher Than Reported in Trials
Study suggests irAEs with PD-L1 therapy for NSCLC occur more frequently in real-world vs clinical trial populations.
Oncologists found to spend more time with nonminority patients discussing care goals than with minority patients.
Researchers presented results of a study on the effects of acupuncture treatments on pain, fatigue, nausea, and other effects of cancer and cancer treatment.
Researchers reviewed cancer incidence in patients with Diamond-Blackfan anemia.
A meta-analysis of 14 randomized, controlled trials was conducted to determine if combining G-CSF with intensified chemotherapy improved overall survival.
Assessment of long-term risks for VTE based on data from almost 30,000 childhood cancer survivors and siblings, with approximately 21 years of follow-up.
A comparison study of 2 approaches to radical hysterectomy found that disease-free and overall survival are worse with minimally invasive procedure than with abdominal open procedure, contradicting previous study findings.
Researchers analyzed data from more than 15,000 patients in Southern California with various cancers to identify clinical factors that contribute to the risk of developing chemotherapy-induced febrile neutropenia.
Results of an open-label phase 2 study demonstrated that a dose-escalation approach can prevent worsening anemia in patients with myelofibrosis undergoing treatment with ruxolitinib.
Survey also shows that Americans may be misinformed about alternative treatments for cancer.
Stem Cell Transplantation Superior to Chemotherapy for Relapsed/Refractory DLBCL, Follicular Lymphoma
A review of therapy options for relapsed/refractory DLBCL and FL compared SCT with chemotherapy/immunotherapy and experimental regimes. Patients fared better with SCT than other treatment modalities.
Survivors of head, neck cancers almost twice as likely to die from suicide as survivors of other cancers.
A retrospective evaluation of patients treated at a tertiary cancer center demonstrated that patients with Hodgkin lymphoma experienced periods of actionable distress in survivorship, despite a low overall distress burden.
A population-based study compared open abdominal radical hysterectomy with minimally invasive robot-assisted radical hysterectomy, and found a slight edge in survival among those who underwent the open procedure.
In a review of data from the National Health Interview Survey, researchers identified the relationship between short and long sleep durations and diabetes in cancer survivors.
Researchers explored the feasibility of integrating pharmacists into the oncology care team for older patients with cancer to determine the impact this intervention would have on medication management and vaccination uptake.
Guidelines recommend surgical excision as primary treatment modality, and emphasize individualized care.
A snapshot of an international Commission's report on the issues inherent with adverse event reports of hematologic malingnancies in clinical trials.
The goal of this study was to determine how molecular features change when PDAC progresses from a primary tumor to metastatic disease.
A prospective cohort study from Denmark investigated the link between maternal hormonal contraception use before — more than 3 months and within 3 months — and during pregnancy and risk of leukemia in their children.
A prospective analysis of patients with advanced cancer revealed the effect delirium has on palliative care and symptom management at baseline and after 7 days of treatment.
Mistrust, lack of knowledge, unfavorable attitudes are barriers to genomic testing, study participation
Higher recurrence risk linked to older age, more advanced stage, HR-negative tumors.
Survival and progression-free survival were better with nivolumab alone or with ipilimumab vs ipilimumab alone for stage III or IV melanoma with known BRAFV600 mutation, according to results of this randomized study.
The 2016 evidence-based PACC guidelines recommend the use of morphine and ziconotide as effective and safe first-line IT monotherapies for chronic pain.
As immunotherapies gain a stronger foothold as a treatment option for cancer, ASCO and SITC convened a panel to develop recommendations to ensure consistent and efficient clinical trial reporting in immuno-oncology.
A prospective analysis of diets before and after diagnosis revealed dietary habits among patients with colorectal cancer that may help prolong survival.
In a retrospective evaluation, investigators sought to identify risk factors for higher-grade transformation in patients with marginal zone lymphomas.
Using fictional patient profiles and a questionnaire on recommendation procedures, researchers were able to demonstrate a need for standardized tumor board interpretation and recommendation processes worldwide.
A propensity-score matched analysis was used to determine the effect of surgery and postoperative radiotherapy in patients with TNETs.
A study presented at ESMO 2018 demonstrated that incidence of skin toxicity in patients with multiple myeloma undergoing lenalidomide therapy was lower in those who received prior bortezomib.
This is only a test.
Study shows that referrals to palliative care and time to referral are relative to the age of the treating oncologist, with higher numbers and quicker referrals among younger oncologists.
Assessment of a subgroup of a cohort study revealed that many patients undergoing tamoxifen therapy for early-stage breast cancer do not adhere to their prescribed treatment, even though they claim adherence on patient surveys.
Atezolizumab plus nab-paclitaxel prolongs progression-free survival in metastatic disease.
An analysis of pooled data from 4 randomized controlled clinical trials revealed that male and female patients experience different chemotherapy side effects and at different severities, according to a poster presented at ESMO 2018 Congress.
Researchers surveyed 60 breast cancer survivors to determine if their desire to achieve pregnancy had changed after completing treatment. These findings were presented at ESMO 2018 Congress.
Study findings presented at ESMO 2018 Congress revealed the effect of a shorter, 9-week course of trastuzumab on disease-free survival (DFS) and cardiac toxicity in women with HER2-positive breast cancer.
Radiation dose not impacted with light or moderate use of skin treatments, regardless of beam energy, incidence.
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- Cancer Treatment and Research: What Lies Ahead in 2019
- Helping Patients Face the Challenge of Eating Healthy During Cancer Treatment
- Continuous Therapy May Be Beneficial in Patients With Newly Diagnosed Multiple Myeloma
- Regular Physical Activity — Even Initiated Postdiagnosis — Improves Survival for Cancer Patients
- Gastrointestinal Perforation Complicates Management of Mantle Cell Lymphoma
- Brain Exercise Program Eases Chemobrain in Breast Cancer Survivors
- Hormone Therapy for Breast Cancer (Fact Sheet)
- Counseling on the Dangers of Vaping
- Radical Prostatectomy vs Active Surveillance: Results of Nearly 3 Decades of Follow-up
- Potential of Fecal Microbiota Transplantation in Managing Immunotherapy-Associated Colitis
- Ixazomib Maintenance After ASCT Improves Progression-Free, Overall Survival in Multiple Myeloma
- Evolutionary Role of Chemotherapy in Advanced Nasopharyngeal Carcinoma: A Literature-based Network Meta-analysis
- Helping Patients Face the Challenge of Eating Healthy During Cancer Treatment
- Gastrointestinal Perforation Complicates Management of Mantle Cell Lymphoma
- Modernizing Eligibility Criteria Could Increase Access to, Participation in Clinical Trials
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