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Tretinoin Capsules
Leukemias, lymphomas, and other hematologic cancers
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Drug Name:

Tretinoin Capsules Rx

Generic Name and Formulations:
Tretinoin 10mg; soft gelatin caps; contain parabens.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Tretinoin Capsules:

Induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant), characterized by the presence of the t(15;17) translocation and/or the presence of the PML/RARα gene who are refractory to, or who have relapsed from, anthracycline chemotherapy, or for whom anthracycline-based chemotherapy is contraindicated.

Adult:

Use only for induction of remission. 45mg/m2 per day in two divided doses until complete remission is documented. Discontinue 30 days after complete remission or after 90 days of treatment, whichever occurs first.

Children:

See full labeling.

Boxed Warning:

Experienced physician and institution. Retinoic Acid-APl syndrome. Leukocytosis at presentation and rapidly evolving leukocytosis during tretinoin treatment. Teratogenic effects.

Warnings/Precautions:

Confirm APL diagnosis. Monitor for Retinoic Acid-APL (RA-APL) syndrome, leukocytosis, pseudotumor cerebri, or respiratory compromise. Consider temporarily interrupting therapy if moderate to severe RA-APL syndrome develops. Monitor blood counts, coagulation profile, lipids, liver function; consider temporary withdrawal if tests >5XULN. Pregnancy (Cat.D); obtain negative pregnancy test 1 week before starting treatment, counsel patient about need to use 2 effective methods of contraception during, and 1 month after therapy. Nursing mothers: not recommended.

Pharmacological Class:

Retinoid.

Interactions:

Do not administer with Vitamin A. May be potentiated or antagonized by CYP450 enzyme inducers or inhibitors. Caution with anti-fibrinolytic agents; and other agents known to cause pseudotumor cerebri/intracranial hypertension.

Adverse Reactions:

Headache, fever, skin/mucous membrane dryness, bone pain, GI upset, rash, mucositis, pruritus, increased sweating, visual disturbances, alopecia; RA-APL syndrome, leukocytosis, pseudotumor cerebri, hypercholesterolemia/hypertriglyceridemia, others.

Note:

Formerly known under the brand name Vesanoid.

How Supplied:

Contact supplier

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