These medications are not recommended for children and should be used for adults ≥18yrs old, unless otherwise specified.
|betamethasone dipropionate||Sernivo||spray||Apply twice daily for up to max 4wks. Discontinue when control is achieved.|
|clobetasol propionate||Impoyz||crm||Apply twice daily; max 50g/week and 2 consecutive weeks’ treatment per course. Discontinue when control is achieved.|
|Olux||foam||Apply twice daily; max 50g/week or 21 capfuls/week and 2 consecutive weeks’ treatment per course. Discontinue when control is achieved.|
|halobetasol propionate||Bryhali||lotion||Apply once daily for up to 8wks; max 50g/week. Discontinue when control is achieved.|
|Lexette||foam||Apply twice daily for up to 2wks; max 50g/week. Discontinue when control is achieved.|
|calcipotriene||Dovonex||crm||Apply twice daily; gently rub in completely.|
|Sorilux||foam||≥4yrs: apply twice daily; gently rub in completely. Apply to scalp when hair is dry.|
|calcipotriene + betamethasone dipropionate||Enstilar||foam||≥12yrs: apply once daily for up to 4wks; max 60g every 4 days. Discontinue when control is achieved.|
|Taclonex||oint, topical susp||Apply once daily for up to 4wks (oint) or 8wks (susp). 12–17yrs: max 60g/week. ≥18yrs: max 100g/week. Discontinue when control is achieved. Oint: limit to max 30% body surface area.|
|calcitriol||Vectical||oint||Apply twice daily in AM & PM; max 200g/week.|
|halobetasol propionate + tazarotene||Duobrii||lotion||Apply once daily; max 50g/week. Discontinue when control is achieved.|
|tazarotene||Tazorac||gel, crm||Apply once daily in the PM. Gel: limit to max 20% body surface area. Initiate with 0.05% strength; may increase to 0.1% as tolerated and clinically indicated.|
|Interleukin-12 and interleukin-23 antagonist1|
|ustekinumab||Stelara||soln for SC inj||12–17yrs: give SC at Weeks 0 and 4, then every 12wks thereafter. (<60kg): 0.75mg/kg; (60–100kg): 45mg; (>100kg): 90mg. ≥18yrs (≤100kg): initially 45mg SC once, then 4wks later, and then once every 12wks; (>100kg): initially 90mg once, then 4wks later, and then once every 12wks.|
|brodalumab||Siliq||soln for SC inj||210mg SC at Weeks 0, 1, and 2, then 210mg every 2wks.|
|ixekizumab||Taltz||soln for SC inj||160mg (given as two 80mg SC injs) at Week 0, then 80mg at Weeks 2, 4, 6, 8, 10, and 12, then 80mg every 4wks.|
|secukinumab||Cosentyx||soln or lyophilized pwd for SC inj||300mg (given as two 150mg SC injs) at Weeks 0, 1, 2, 3, and 4 then 300mg every 4wks. For some patients, 150mg dose may be acceptable.|
|guselkumab||Tremfya||soln for SC inj||100mg SC at Weeks 0 and 4, then every 8wks thereafter.|
|risankizumab-rzaa||Skyrizi||soln for SC inj||150mg (two 75mg SC injs) at Weeks 0 and 4, then every 12wks thereafter.|
|tildrakizumab-asmn||Ilumya||soln for SC inj||100mg SC at Weeks 0 and 4, then every 12wks thereafter.|
|methoxsalen2||Oxsoralen-Ultra||soft gel caps||Take 1.5–2hrs before UVA exposure with low fat food or milk. (<30kg): 10mg; (30–50kg): 20mg; (51–65kg): 30mg; (66–80kg): 40mg; (81–90kg): 50mg; (91–115kg): 60mg; (>115kg): 70mg.|
|Tumor necrosis factor (TNF) blockers1|
|adalimumab||Humira||soln for SC inj||Initially 80mg SC, followed by 40mg every other week 1wk after initial dose.|
|certolizumab pegol||Cimzia||soln or pwd for SC inj||400mg (two 200mg inj at separate sites) SC every other week. ≤90kg: may consider 400mg on Day 1, then at Weeks 2 and 4, followed by 200mg every other week.|
|etanercept||Enbrel||soln or pwd for SC inj; soln for autoinjector||Give by SC inj. ≥4yrs: (<63kg): 0.8mg/kg (max 50mg) weekly; (≥63kg): 50mg weekly. ≥18yrs: initially 50mg SC twice weekly for 3mos (initial doses of 25mg or 50mg per week were shown to be efficacious). Maintenance: 50mg once weekly.|
lyophilized pwd for IV infusion
|5mg/kg IV over ≥2hrs at Weeks 0, 2, 6, then once every 8wks.|
|acitretin||Soriatane||caps||25–50mg once daily with main meal; may discontinue when lesions resolve. May repeat if relapse occurs.|
|apremilast||Otezla||tabs||Starting on Day 1: 10mg in the AM. Day 2: 10mg in AM and 10mg in PM. Day 3: 10mg in AM and 20mg in PM. Day 4: 20mg in AM and 20mg in PM. Day 5: 20mg in AM and 30mg in PM. Following on Day 6 and thereafter: 30mg twice daily (AM & PM).|
|cyclosporine||Gengraf3||caps, oral soln||1.25mg/kg twice daily; may increase after 4wks by 0.5mg/kg/day, then adjust at 2-week intervals; max 4mg/kg/day.|
|methotrexate||Otrexup||soln for SC inj||10–25mg once weekly using an oral, IM, SC, or IV form; max 30mg/wk. Use alternative MTX form in patients requiring oral, IM, IV, intra-arterial, or intrathecal dosing, doses <10mg/wk or >25mg/wk, high-dose regimens, or dose adjustments <5mg increments.|
1 These medications should only be used under the guidance and supervision of a physician.
2 Intended to be administered only in conjunction with a schedule of controlled doses of long wave UV radiation. See full labeling for UVA exposure schedule.
3 Not bioequivalent to all other forms of cyclosporine; do not interchange without physician supervision.
Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling.
This article originally appeared on MPR