|ANTIBIOTICS + CORTICOSTEROIDS|
|ciprofloxacin 0.3% +
|ciprofloxacin 0.3% +
fluocinolone acetonide 0.025%
|ciprofloxacin 0.2% + hydrocortisone 1%||Cipro HC Otic||Rx||susp|
|colistin sulfate 3mg/mL +
neomycin sulfate 3.3mg/mL +
hydrocortisone acetate 10mg/mL +
thonzonium bromide 0.5mg/mL
|Coly-Mycin S Otic1||Rx||susp|
|polymyxin B sulfate
10000 U/mL +
neomycin sulfate 3.5mg/mL +
|carbamide peroxide 6.5%||Auro||OTC||soln|
|Murine Ear Drops||OTC||soln|
|isotonic, desalinated seawater||Murine Earigate||OTC||spray|
|Murine Earigate Kids||OTC||reduced-pressure spray|
|isopropyl alcohol 95% +
anhydrous glycerin 5%
|fluocinolone acetonide 0.01%||Dermotic Oil3||Rx||drops|
Warming an otic product by holding the bottle in hand for 1−2 min may minimize dizziness and pain on application; do not heat above body temperature.
|Classes & Pharmacology|
Antibiotics: Neomycin is active against S. aureus, E. coli, H. influenzae, K. pneumoniae, Enterobacter, Neisseriae, P. aeruginosa. Neomycin can cause hearing loss and should usually not be used for more than 10 days; it can also cause sensitization. Ofloxacin is a fluoroquinolone antibiotic active against S. aureus, P. aeruginosa, P. mirabilis, S. pneumoniae, H. influenzae, M. catarrhalis. Ciprofloxacin is a fluoroquinolone antibiotic active against S. aureus, P. mirabilis, P. aeruginosa. Colistin is active against most strains of gram negative bacteria including P. aeruginosa, E. coli, K. pneumoniae, Aerobacter.
Corticosteroids: Hydrocortisone controls inflammation, edema, pruritus. It should not be used in the presence of local viral infections and it can impede wound healing.
Ceruminolytics: Carbamide peroxide mechanically softens and loosens excessive ear wax. Triethanolamine polypeptide oleate is a surfactant that breaks up cerumen.
Drying Agents: Isopropyl alcohol and anhydrous glycerin have surface-tension releasing properties which dislodge trapped water from the sides of the ear canal, allowing it to run out or evaporate.
Preservatives: Thimerosal (a mercury derivative), parabens, sulfites, oxyquinoline sulfate, or benzalkonium chloride may cause sensitization. Benzalkonium chloride also reduces surface tension.
Excipients and Vehicle: Propylene glycol, polysorbate 80 aid in product formulation. Products that contain hydrochloric acid should be used only in the presence of an intact eardrum.
Surfactants: Thonzonium bromide is a surface-active agent that promotes tissue contact by dispersion and penetration of the cellular debris and exudate.
1Contains thimerosal; 2Contains sulfites; 3Contains peanut oil
This article originally appeared on MPR