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TRICOR
Hyperlipoproteinemias
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Drug Name:

TRICOR Rx

Generic Name and Formulations:
Fenofibrate 48mg, 145mg; tabs.

Company:
AbbVie

Therapeutic Use:

Indications for TRICOR:

Adjunct to diet in hypertriglyceridemia (Types IV and V), and to reduce elevated total-C, LDL-C, apo B, and TG, and to increase HDL-C, in primary hypercholesterolemia and mixed dyslipidemia (Types IIa and IIb). Limitations of use: not shown to reduce coronary heart disease morbidity and mortality in a controlled trial of patients with type 2 diabetes mellitus.

Adult:

Take without regard to food. Hypertriglyceridemia: 48–145mg/day, adjust at 4–8 week intervals. Hypercholesterolemia, dyslipidemia: initially 145mg/day. Renal impairment or elderly: initially 48mg/day. Discontinue if inadequate response after 2 months on max dose.

Children:

Not established.

Contraindications:

Hepatic dysfunction. Primary biliary cirrhosis. Severe renal dysfunction. Gallbladder disease.

Warnings/Precautions:

Renal impairment. Monitor CBCs for first year; monitor liver function; discontinue if ALT (SGPT) levels >3×ULN persist. Discontinue if markedly elevated CPK levels, myopathy, gallstones, hypersensitivity reactions (acute and delayed), or severely depressed HDL-C levels occur (do not reinitiate). Pregnancy. Nursing mothers: not recommended (during and for 5 days after final dose).

Pharmacological Class:

Fibrate.

Interactions:

Avoid statins. Potentiates oral anticoagulants (monitor). Allow at least 1hr before or 4–6hrs after bile acid sequestrants. Caution with immunosuppressants (eg, cyclosporine), colchicine, other nephrotoxic drugs.

Adverse Reactions:

Abnormal liver function tests, elevated CPK, rhinitis, myopathy, cholelithiasis, pancreatitis, increased serum creatinine, hypersensitivity reactions (may be severe), rash; rare: rhabdomyolysis, transient hematologic changes, blood dyscrasias.

Generic Availability:

YES

How Supplied:

Tabs—90

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