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TOVIAZ
Overactive bladder/enuresis
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Drug Name:

TOVIAZ Rx

Generic Name and Formulations:
Fesoterodine fumarate 4mg, 8mg; ext-rel tabs.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for TOVIAZ:

Overactive bladder (OAB) with urge urinary incontinence, urgency, and frequency.

Adult:

Swallow whole with liquid. 4mg once daily; max 8mg once daily. Severe renal impairment (CrCl<30mL/min) or concomitant potent CYP3A4 inhibitors: max 4mg/day.

Children:

Not established.

Contraindications:

Urinary or gastric retention. Uncontrolled narrow angle glaucoma.

Warnings/Precautions:

Severe hepatic impairment: not recommended. Discontinue promptly if angioedema with upper airway swelling occurs. Bladder outlet obstruction. Controlled narrow angle glaucoma. Myasthenia gravis. Decreased GI motility (eg, severe constipation). Hepatic or renal dysfunction. Monitor for CNS effects after treatment initiation or dose increases; consider dose reduction or discontinuation if occur. Exposure to high environmental temperatures. Pregnancy. Nursing mothers.

Interactions:

Potentiated by potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, clarithromycin); see Adults. Additive effects with other antimuscarinic or anticholinergic agents. Monitor with warfarin.

Pharmacological Class:

Muscarinic antagonist.

Adverse Reactions:

Dry mouth, constipation, urinary retention/UTI, blurred vision, dry eyes, back pain, insomnia, dyspepsia, cough; CNS effects (eg, dizziness, headache, somnolence).

Metabolism:

Hepatic (CYP2D6, CYP3A4).

Elimination:

Renal (primarily), fecal.

Generic Availability:

NO

How Supplied:

Tabs—30

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