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TOVIAZ
Overactive bladder/enuresis
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Drug Name:

TOVIAZ Rx

Generic Name and Formulations:
Fesoterodine fumarate 4mg, 8mg; ext-rel tabs.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for TOVIAZ:

Overactive bladder (OAB) with urge urinary incontinence, urgency, and frequency.

Adult:

Swallow whole with liquid. 4mg once daily; may increase to max 8mg once daily. Severe renal impairment (CrCl<30mL/min) or concomitant potent CYP3A4 inhibitors: max 4mg/day.

Children:

Not established.

Contraindications:

Urinary or gastric retention. Uncontrolled narrow angle glaucoma.

Warnings/Precautions:

Severe hepatic impairment: not recommended. Bladder outlet obstruction. Decreased GI motility (eg, severe constipation). Controlled narrow-angle glaucoma. Myasthenia gravis. Monitor for CNS effects esp. after initiation or dose increases; consider reducing dose or discontinue if occurs. Renal or hepatic impairment. Exposure to high environmental temperatures. Pregnancy. Nursing mothers.

Pharmacological Class:

Muscarinic antagonist.

Interactions:

Potentiated by potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, clarithromycin); see Adult. Additive effects with other antimuscarinic or anticholinergic agents.

Adverse Reactions:

Dry mouth, constipation, urinary retention/UTI, dyspepsia, dry eyes; angioedema (discontinue if occurs), CNS effects (eg, headache, dizziness, somnolence).

Metabolism:

Hepatic (CYP2D6, CYP3A4).

Elimination:

Renal (primarily), fecal.

Generic Availability:

NO

How Supplied:

Tabs—30

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