Adavosertib Appears Active but Toxic in Advanced Uterine Cancer
Adavosertib is active but not well tolerated in patients with recurrent or persistent uterine serous carcinoma, a phase 2 study suggests.
Diagnosis & Disease Information
Risk of Uterine Diseases, Cancers Up With Tamoxifen Treatment
After adjustment for confounding variables, risk of endometrial cancer was increased almost fourfold with tamoxifen treatment.
ePRO Tool Improves Symptom Management in an Outpatient Gynecologic Cancer Clinic
Investigators sought to determine if electronic patient-reported outcome tools with the PROMIS network improved identifying patients with severe symptoms and increased referrals to ancillary support services.
Methotrexate Courses for Postmolar GTN Unchanged After Re-Cutterage
Researchers sought to examine the affect of uterine re-curettage on the number of methotrexate courses required for patients with postmolar gestational trophoblastic neoplasia.
Adding Trastuzumab to Uterine Serous Carcinoma Treatment Extended PFS
Researchers explored whether adding trastuzumab to carboplatin and paclitaxel would improve survival outcomes for patients with advanced/recurrent disease with overexpressed HER2/neu.
Comorbidities May Predict Non-Home Discharge After Hysterectomy
Presence of 1 risk factor or 2 or more risk factors is associated with non-home discharge after hysterectomy for gynecologic malignancy.
Perioperative Pain Control Reduces Need for Postoperative Narcotics After Hysterectomy for Uterine Cancer
Preoperative intravenous acetaminophen plus local infiltration of LB during hysterectomy and surgical staging of uterine cancer may reduce the need for postoperative narcotics.
Chemotherapy or VBT Improve Survival in Uterine Papillary Serous Carcinoma
Use of chemotherapy or vaginal brachytherapy (VBT) may improve survival among patients with early-stage uterine papillary serous carcinoma.
PI3K/mTOR Inhibitor Demonstrates Efficacy in Some Uterine Sarcomas
A new generation dual PI3K/mTOR inhibitor shows promise in treating leiomyosarcomas with the protein P-S6S240.
BRCA1 Mutations May Raise Risk of Serous and Serous-Like Uterine Cancer
Although overall risk for uterine cancer after risk-reducing salpingo-oophorectomy is not increased, the risk of serous/serous-like endometrial carcinoma is higher for BRCA1+ women.
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