Adding ovarian suppression to tamoxifen reduced recurrence for some premenopausal breast cancer
Among premenopausal women with early stage, HR-positive breast cancer, the addition of ovarian suppression to tamoxifen reduced breast cancer recurrence.
Diagnosis & Disease Information
Tamoxifen found to lower breast cancer rates among high-risk women in trial
The International Breast Cancer Intervention Study-I (IBIS-I) trial found that tamoxifen significantly decreased the incidence of all breast cancers, according to data presented at the 2014 San Antonio Breast Cancer Symposium.
Preventative therapies for healthy women at high risk of breast cancer
SERMs and aromatase inhibitors have been proven to be excellent agents in the preventive setting for ER-positive breast cancer, but newer agents must be found specifically for ER-negative breast cancers, which mostly occur in premenopausal women.
Gel formulation of tamoxifen significantly reduces side effects related to the oral formulation
A gel form of tamoxifen applied to the breasts of women with noninvasive breast cancer reduced the growth of cancer cells to the same degree as the drug taken in oral form but with fewer side effects.
Sleeping in darkness boosts breast cancer drug effectiveness
Keeping a light on at night can suppress the body’s production of a hormone called melatonin, possibly reducing the effectiveness of the breast-cancer drug tamoxifen, a study suggests.
Exposure to dim light at night may lead to tamoxifen resistance in breast cancer
For rats bearing human breast tumors, exposure to dim light at night made the tumors resistant to the breast cancer drug tamoxifen, according to recently published data.
Gene marker may help predict breast cancer response to tamoxifen
Researchers have identified genes that may help predict whether a patient with estrogen receptor (ER)-positive breast cancer is likely to benefit from tamoxifen therapy.
Skin gel helps fight against breast cancer
A gel containing the drug tamoxifen and applied to the skin was as effective as the pill form in reducing the growth of breast cancer cells in women with noninvasive cancer.
Drug resistance reversed when tamoxifen is paired with antimalarial agent
The antimalarial drug hydroxychloroquine (HCQ) reverses resistance to tamoxifen in mice, according to investigators.
ASCO: Exemestane more effective than tamoxifen for early breast cancer
For premenopausal women with hormone receptor-positive early breast cancer, exemestane plus ovarian function suppression (OFS) is superior to tamoxifen plus OFS.
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