Publishers Alliance Archives - Oncology Nurse Advisor

A Prospective Study on Urine Alkalization With an Oral Regimen Consisting of Sodium Bicarbonate and Acetazolamide in Patients Receiving High-dose Methotrexate

October 11, 2019

[Cancer Management and Research] Researchers sought an alternative regimen for urine alkalization in patients receiving high-dose methotrexate. The typical regimen, IV sodium bicarbonate, has been on shortage. This study determined the safety of an oral regimen of sodium bicarbonate and acetazolamide to achieve a urine pH >7, which is necessary for safe administration of high-dose methotrexate.

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Do Early HER2-overexpression Breast Cancer Patients Benefit From Undergoing Neoadjuvant Trastuzumab and Mastectomy? A Meta-analysis

October 4, 2019

[Cancer Management and Research] In a meta-analysis of 12 clinical studies, researchers sought to determine if patients with HER2-overexpression breast cancer experienced better OS with neoadjuvant or adjuvant trastuzumab, and to assess LRR rate in women with this tumor and treatment after mastectomy and after BCT.

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Recent Advances and Application of PD-1 Blockade in Sarcoma

September 27, 2019

[OncoTargets and Therapy] Despite the success of PD-1 blockade in the treatment of other solid tumors, only surgery at the early stage is an effective curative treatment of sarcoma. This review summarizes recent progress achieved in the use of anti-PD-1 therapy for sarcoma.

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Primary Spinal Epidural Diffuse Large B-cell Lymphoma With Paraplegia as the First Manifestation: A Case Report

September 20, 2019

[OncoTargets and Therapy] In this patient case, after 2 misdiagnoses and surgery, a diagnosis of spinal epidural DLBCL was made and the patient was treated with 6 cycles of R-CHOPE. The authors explain when to suspect PSEL in patients with spinal cord compression.

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Microwave Ablation Compared With radiofrequency Ablation for Treatment of Hepatocellular Carcinoma and Liver Metastases: A Systematic Review and Meta-analysis

September 13, 2019

[OncoTargets and Therapy] This systematic review and meta-analysis compared MWA and RFA in the treatment of minimally invasive liver cancer. Local tumor progression, technique efficacy, OS, DFS, intrahepatic de novo lesions, extrahepatic metastases, length of stay, and complications were analyzed.

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Mammographic Density Parameters and Breast Cancer Tumor Characteristics Among Postmenopausal Women

September 6, 2019

[Breast Cancer: Targets and Therapy] A population-based case-control study explored whether the association between mammographic density as a risk factor for breast cancer differs across breast cancer tumor subtypes.

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Cardiovascular Disease-related Chronic Conditions Among Veterans Affairs nonmetastatic Colorectal Cancer Survivors: A Matched Case–control Analysis

August 30, 2019

[Cancer Management and Research] This retrospective study investigated the likelihood of CVD-related chronic conditions being diagnosed in survivors of nonmetastatic CRC and of effective management of these conditions over 12 months following CRC diagnosis.

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Ultra-late Recurrence of Non-small Cell Lung Cancer Over 10 Years After Curative Resection

August 23, 2019

[Cancer Management and Research] Researchers analyzed data to determine the features of ultra-late recurrence of NSCLC, defined as recurrent disease more than 10 years after curative resection.

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Status of, and Strategies for Improving, Adherence to HCC Screening and Surveillance

August 16, 2019

[Journal of Hepatocellular Carcinoma] Although prognosis is poor for patients with hepatocellular carcinoma (HCC), especially those with cirrhosis, a prolonged subclinical growth period offers a window of time for curative treatment. In this review, researchers discuss the current status of screening, and what can be done to improve its potential.

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Beliefs Held by Breast Surgeons That Impact the Treatment Decision Process for Advanced Breast Cancer Patients: A Qualitative Study

August 8, 2019

[Breast Cancer: Targets and Therapy] A series of semi-structured interviews with breast specialists revealed how surgeons’ own beliefs regarding patients’ ability to accept death influenced how they managed treatment decision making.