Early Radiotherapy Preserves Vision in Certain Children With Glioma
Early radiotherapy may preserve visual acuity for certain children with sporadic optic pathway/hypothalamic gliomas.
Pediatric Cancer
Extended Induction Chemotherapy Does Not Improve Survival in High-Risk Neuroblastoma
Researchers found that the therapy did not improve EFS or OS in high-risk patients and also led to an increase in toxic side effects.
Blinatumomab Improves Outcomes in Children With High-Risk B-ALL
A multicenter, randomized, phase 3 trial compared blinatumomab with intensive multidrug consolidation chemotherapy in children with high-risk, first-relapse B-cell ALL.
Extensive Molecular Characterization Uncovers Actionable Alterations in Many High-Risk Pediatric Cancers
As part of the Zero Childhood Cancer Program, high-risk pediatric tumors were characterized by whole-genome sequencing, RNA sequencing, and methylation profiling.
FDA, EMA Call for Coordinated Submission of Plans to Study Pediatric Cancers
The FDA and EMA expressed the need for trial sponsors to coordinate their submissions of initial pediatric study plans and pediatric investigation plans for new oncology drugs.
p16INK4a Expression Increased in Young Cancer Survivors
Signs of age acceleration at molecular level also seen in frail survivors, in children after cancer therapy.
Hearing Loss Associated With Neurocognitive Deficits in Pediatric Cancer Survivors, Study Finds
A large cross-sectional cohort study investigated the relationship between hearing loss and measures of neurocognition in survivors of childhood cancers.
Management of Refractory Pediatric Sarcoma: Current Challenges and Future Prospects
[OncoTargets and Therapy] While multimodal treatment can be curative in select cases of r/r pediatric sarcoma, treatment refractoriness remains a tremendous hurdle for clinicians.
Mylotarg Indication Expanded to Include Newly-Diagnosed Pediatric AML
The FDA has expanded the approval of Mylotarg (gemtuzumab ozogamicin; Pfizer) to include treatment of patients aged 1 month and older with newly-diagnosed CD33-positive acute myeloid leukemia.
Clinical Practice Guidelines Released for Managing Pain in Children With Cancer Undergoing Needle-Related Procedures
Inadequate pain management during needle procedures has been associated with increased anxiety and decreased treatment compliance in children with cancer.
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