Late Effects With Chronic GVHD in Children After Hematopoietic Cell Transplantation
Researchers sought to determine the effect of chronic graft-versus-host disease on late effects after HCT in pediatric cancer survivors.
Pediatric Cancer
Genetic Alterations ID’d in Many Pediatric Solid Tumors
86 percent of extracranial solid tumors in pediatric patients had genomic alterations with potential for impact on care.
Race, Ethnicity Underreported in Early Phase Pediatric Cancer Trials
Race and ethnicity were reported in less than 25% of the trials studied.
Health Insurance Status Linked to Disparities in Pediatric Cancer Diagnosis
Disparities in cancer diagnoses among pediatric patients are partly a result of disparities in health insurance coverage, a study suggests.
1990 to 2019 Saw Decrease in Global Burden of Childhood Cancer
Decreases in all regions, but highest rates in 2019 seen in countries with lower sociodemographic index.
Late Outcomes Support Radiation-Limiting Treatment Strategies for Pediatric Glioma
Use of radiation decreased over time, while use of surgery alone increased.
Survivors of Medulloblastoma Have Greater Risk of Stroke, Severe Hearing Loss
Medulloblastoma survivors had an increased risk of long-term adverse outcomes.
Larotrectinib Produces “Remarkable” Responses in NTRK Fusion-Positive CNS Tumors
The median duration of response was not reached at a median follow-up of 26 months.
Molecular Analysis Refines Diagnosis, Enables Personalized Treatment for Pediatric CNS Tumors
Of the patients who completed follow-up, 60% had a targeted therapy recommendation.
RNA Sequencing Reveals Clinically Relevant Alterations in Pediatric Low-Grade Glioma
RNA sequencing confirmed the alterations most frequently described in low-grade glioma and revealed rare gene fusions.
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