Late Effects With Chronic GVHD in Children After Hematopoietic Cell Transplantation
Researchers sought to determine the effect of chronic graft-versus-host disease on late effects after HCT in pediatric cancer survivors.
Researchers sought to determine the effect of chronic graft-versus-host disease on late effects after HCT in pediatric cancer survivors.
86 percent of extracranial solid tumors in pediatric patients had genomic alterations with potential for impact on care.
Race and ethnicity were reported in less than 25% of the trials studied.
Disparities in cancer diagnoses among pediatric patients are partly a result of disparities in health insurance coverage, a study suggests.
Decreases in all regions, but highest rates in 2019 seen in countries with lower sociodemographic index.
Use of radiation decreased over time, while use of surgery alone increased.
Medulloblastoma survivors had an increased risk of long-term adverse outcomes.
The median duration of response was not reached at a median follow-up of 26 months.
Of the patients who completed follow-up, 60% had a targeted therapy recommendation.
RNA sequencing confirmed the alterations most frequently described in low-grade glioma and revealed rare gene fusions.