A small, phase I clinical trial indicates the experimental drug guadecitabine is safe in combination with the chemotherapy drug irinotecan, and it may overcome resistance to irinotecan in patients with metastatic colorectal cancer.
A new biomarker measurement might improve the accuracy of prognostic testing and precision medicine in uveal melanoma.
Adrenaline acted on breast cancer cells via the cell surface beta2-adrenoceptor to promote disease growth and invasion, suggesting that beta-blockers might be helpful as adjuvant therapy for patients with aggressive breast cancer.
Adding radiotherapy to chemotherapy and surgery reduced the number of local disease recurrences but did not affect distant recurrences or survival.
Cancer metastasis is dynamically regulated by cancer-associated fibroblasts (CAFs), a cancer-promoting component in the tumor microenvironment. Eliminating the CAFs after 10 days dramatically increases the risk of the primary tumor metastasis to the lungs and bones in a mouse model.
Current sequencing technology has enabled an analysis of cancer evolution that directs research attention away from the search for genes that enable metastasis and toward genes that are mutated early during tumorigenesis.
A gene previously thought only to be expressed in the brain, GABAA receptor alpha3 (Gabra3), promotes breast cancer migration, invasion, and metastasis.
PRAME mRNA expression is independent prognostic biomarker in Class 1 uveal melanoma.
The protein EPHA2, a receptor on the lining of blood vessels, controls how breast cancer cells metastasize around the body. These findings shed light on how cancer cells exit blood vessels to enter a new part of the body.
Researchers visualized the origins of cancer from the first affected cell through its spread in a live animal: the zebrafish. This research may change scientific understanding of melanoma and other cancers leading to new treatments that can be administered before the cancer has taken hold.
