Tumor-Immune Interactions May Contribute to Intratumoral Heterogeneity in Hepatocellular Carcinoma
Information on ITH can provide insight into the clonal evolutionary processes occurring within the tumor in response to prior treatment.
Hepatocellular Carcinoma
Tumor Size and Stiffness May Be Relevant Biomarkers of Response to ICIs in Hepatocellular Carcinoma
The median change in HCC tumor size between responders and nonresponders was statistically significant.
Study Finds Atezolizumab Plus Bevacizumab Prolongs Maintenance of QoL Compared With Sorafenib in Certain Patients With HCC
In this study, deterioration in specific PROs required a drop of at least 10 points from baseline.
Prior Exposure to Antibiotics or Antacids Did Not Reduce Immunotherapy Response in Advanced HCC
Researchers hypothesized that because prior studies have demonstrated that common drugs can affect the microbiome, these medications could also impact IO efficacy in HCC.
Study Reveals Differences Between the Genomic Profiles of Primary Tumors and Metastatic Lesions in Intrahepatic Cholangiocarcinoma
Previous genomic profiling studies have identified potentially targetable alterations in IDH1 and FGFR2 in primary tumor specimens of some patients with IHCC.
Socioeconomic and Survival Differences Among Minorities With Hepatocellular Carcinoma in Florida
[Journal of Hepatocellular Carcinoma] In this study, investigators sought to determine how socioeconomic differences influenced outcomes for patients in Florida with HCC. They found that despite having lower socioeconomic status, Hispanic patients with HCC fared better than both black and white patients with HCC.
New Data on HRQOL for Patients With Hepatocellular Carcinoma From the KEYNOTE-240 Trial
Analysis of a cohort from the KEYNOTE-240 trial showed that health-related quality of life for patients with HCC was similar across the 2 arms of the study.
Microwave Ablation Compared With radiofrequency Ablation for Treatment of Hepatocellular Carcinoma and Liver Metastases: A Systematic Review and Meta-analysis
[OncoTargets and Therapy] This systematic review and meta-analysis compared MWA and RFA in the treatment of minimally invasive liver cancer. Local tumor progression, technique efficacy, OS, DFS, intrahepatic de novo lesions, extrahepatic metastases, length of stay, and complications were analyzed.
Status of, and Strategies for Improving, Adherence to HCC Screening and Surveillance
[Journal of Hepatocellular Carcinoma] Although prognosis is poor for patients with hepatocellular carcinoma (HCC), especially those with cirrhosis, a prolonged subclinical growth period offers a window of time for curative treatment. In this review, researchers discuss the current status of screening, and what can be done to improve its potential.
Intermediate Stage Hepatocellular Carcinoma: A Summary Review
[Journal of Hepatocellular Carcinoma]
