CRISPR Illustrates Progression of Normal Blood Cells to Leukemia, Precursor Diseases
Genome editing technology illustrates progression of normal blood cells to leukemia.
Diagnosis & Disease Information
Immune Cells Are Biologically Older After Hematopoietic Cell Transplantation
Hematopoietic stem cell transplantation (HCT) is found to increase expression of a genetic code used to make proteins, leading to a biological aging of immune cells equivalent to 30 years of chronological age.
Vitamin C Enhances Epigenetic Treatments in Acute Myeloid Leukemia and Myeloid Dysplastic Syndrome
Research using cancer cell lines demonstrated that supplementing standard epigenetic therapy with vitamin C enhanced the drug’s antineoplastic action.
Costs, Hospital Stays for BSIs Significant in Pediatric Oncology Outpatient Setting
Ambulatory bloodstream infections in pediatric oncology and stem cell transplant patients result in significant health care charges and extended hospital admissions.
Bone Marrow vs Bloodstream: Stem Cell Source Influences Transplantation Outcomes
Blood stem cells derived from donor bone marrow resulted in better self-reported psychological well-being and fewer GVHD symptoms.
Gene Expression Alters Bone Marrow Environment in MGUS, Leading to Multiple Myeloma
Researchers discovered that changes in the bone marrow needed for multiple myeloma to grow have already taken hold in patients with MGUS.
Dose of Transplanted Blood-Forming Bone Marrow Cells Affects How Transplanted Cells Act
Bone marrow transplantation can be improved by optimizing the dose of transplanted hematopoietic stem cells, according to recent results from a mouse model.
Frailty Is a Concerning Factor Among Young Bone Marrow Transplant Survivors
Incidence of frailty among young survivors of bone marrow transplant is similar to that of the elderly population, and increases the risk of death compared with nonfrail survivors.
Risk-specific Prevention Strategies Effectively Reduce Falls on Malignant Hematology Unit
High-risk medications can increase falls in patients undergoing treatment for malignant hematology, but implementing risk-specific fall prevention strategies can ameliorate the effects of the drugs.
Corticosteroid Prophylaxis Reduces Risk of Graft-versus-host Disease in Patients Undergoing Haploidentical Transplantation
Prophylactic low-dose corticosteroid was significantly associated with relatively low risk of GVHD grades II to IV and rapid platelet recovery in patients undergoing haploidentical transplantation.
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