Ofatumumab Plus Hyper-CVAD for Newly Diagnosed (Ph)-Negative, CD20-Positive B-Cell ALL
Combined ofatumumab and hyper-CVAD is a safe and active treatment for adult patients with (Ph)-negative, CD20-positive B-cell ALL.
Hematologic Cancers
Inqovi, an Oral Therapy for Myelodysplastic Syndromes, Gets FDA Approval
The administration of cedazuridine with decitabine prevents the degradation of decitabine by CDA in the gastrointestinal tract and liver increasing its systemic exposure.
Considerations for the Diagnostic Work-Up of Breast Implant–Associated Lymphoma
Flow cytometry may provide an efficient, sensitive, and specific tool for the differential diagnosis of breast implant–associated ALCL, but a cell block may be able to answer additional questions about the disease.
Exercise, Supportive Care Are Key to Managing Cancer-Related Fatigue in Patients With Cancer
Research findings from ESMO confirm that patients with cancer can improve their symptoms of CRF if they “avoid inactivity”; in addition, greater use of supportive care can also help.
Cognitive Impairment Affects Survival Outcomes in Geriatric Patients Undergoing Allogeneic HCT
An analysis of more than 300 patients with hematologic cancer found that cognitive impairment had a negative effect on outcomes, whereas age and IADLs did not.
Methotrexate-Induced Acute Kidney Injuries in Patients with Hematologic Malignancies
Upon starting methotrexate treatment, LDH and albumin levels may be signals for AKIs in patients with hematologic malignancies.
Study Finds Vancomycin Increased Risk for Cytomegalovirus Reactivation After Hematopoietic Cell Transplant
A retrospective study of CMV-seropositive adults receiving allogeneic HCT and CMV-seronegative HLA-matched sibling donors found that vancomycin exposure before HCT increased the risk for CMV reactivation.
Immunoglobulin Assessment For Stratifying Prognosis, Target Therapy in AML
For patients with AML, high immunoglobulin expression is linked to monocytic differentiation, dysplasia, and poorer prognosis.
Study Finds Higher Incidence of Atrial Fibrillation With Ibrutinib Therapy
Patients with chronic lymphocytic leukemia who are treated with ibrutinib may have a higher incidence of atrial fibrillation than previously thought.
Ruxolitinib in Glucocorticoid-Refractory Acute Graft-vs-Host Disease After Allogeneic Stem Cell Transplantation
For patients with GVHD, ruxolitinib improves efficacy outcomes compared with 9 other commonly used options.
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