Study Finds Patients With Rare Ovarian Cancer Develop Chemoresistance
Patients with low-grade serous carcinoma of the ovary or peritoneum (LGSC) developed chemoresistance to neoadjuvant platinum-based therapy.
Gynecologic Cancers
Longitudinal MicroRNAs Lacked Predictive Value in Ovarian Cancer
Study results differ from prior research into microRNAs as predictive biomarkers.
Study Suggests QoL Assessments Do Not Support First-Line Combination Chemotherapy With Weekly Paclitaxel for Epithelial Ovarian Cancer
This analysis focused on QoL end points associated with different dosing schedules for first-line carboplatin-paclitaxel in a predominantly European population with EOC.
Bowel Procedure During Ovarian Surgery Linked to Higher Odds of Surgical Infection
The odds of developing a surgical infection after cytoreductive surgery for ovarian cancer more than doubled in women who had bowel resection or repair.
Radiotherapy for Cervical Cancer: An Introduction to ASTRO’s Clinical Practice Guideline
The consensus guideline, drafted by an ASTRO-convened expert task force, offers recommendations about radiotherapy, including brachytherapy, and chemoradiation, in different stage-of-disease and treatment-strategy settings.
Study Reveals Practice Gap for Patients Undergoing Endometrial Biopsy
The trajectory of follow-up care for women undergoing a failed endometrial biopsy has been largely unexplored.
TP53 Mutations Present in HPV-Negative Vulvar Cancer
In a whole-exome analysis, the most common mutations occurred in TP53, and mutations in other known cancer-associated genes were identified in women with HPV-negative vulvar cancer.
Neoadjuvant Chemotherapy Increases Immunogenicity of High-Grade Serous Ovarian Cancer
This study sought to address outstanding questions regarding tumor heterogeneity in the setting of HGSOC, including its relationship with treatment response.
FDA Approves Keytruda for Tumor Mutational Burden-High Cancer
The accelerated approval was based on data from a prospectively-planned retrospective analysis of 10 cohorts of patients with various previously treated unresectable or metastatic solid tumors with TMB-H who were enrolled in the open-label phase 2 KEYNOTE-158 trial.
Adverse Event Comparison in Patients With Cervical and Endometrial Cancer After IRMT or Standard Radiotherapy
Clinicians may be underappreciating the extent of adverse events in women with cervical and endometrial cancer who undergo radiotherapy.
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