Ruxolitinib in Glucocorticoid-Refractory Acute Graft-vs-Host Disease After Allogeneic Stem Cell Transplantation
For patients with GVHD, ruxolitinib improves efficacy outcomes compared with 9 other commonly used options.
Diagnosis & Disease Information
Preliminary Evidence Supports Benefit of Urinary-Derived hCG in Acute GVHD
In this phase I clinical trial, 2 different cohorts of patients with acute GVHD received subcutaneous injections of uhCG along with standard-of-care treatment.
Novel Approach Prevents GVHD After Hematopoietic Stem Cell Transplantation
An international team developed an approach to hematopoietic stem cell transplantation that prevents GVHD while preserving the benefits of the therapy.
Recently Identified Biomarkers Found to Warn of Chronic Graft-vs-Host Disease in Marrow Transplant Patients
Researchers recently identified CXCL10, a protein that could act as a biomarker for chronic graft-versus-host disease (cGVHD), a long-term adverse effect that develops in some patients after undergoing blood and bone marrow transplant.
Corticosteroid Prophylaxis Reduces Risk of Graft-versus-host Disease in Patients Undergoing Haploidentical Transplantation
Prophylactic low-dose corticosteroid was significantly associated with relatively low risk of GVHD grades II to IV and rapid platelet recovery in patients undergoing haploidentical transplantation.
Gut Bacteria Could Reduce GVHD in Patients Undergoing Bone Marrow Transplantation
A short-chain fatty acid made by bacteria in the gut could play an important role in GVHD after allogeneic bone marrow transplant in mice. In human patients who receive bone marrow transplants, GVHD can cause severe gut damage.
Antibody Therapy Beneficial for Patients With Leukemia Undergoing Stem Cell Transplant
Results for patients with acute leukemia that received the antibody showed lower incidence of chronic graft-versus-host disease post-transplant.
Genetic variant increases risk of graft-versus-host disease in HSCT
Rejection seen with high-expression allele recipient, low-expression allele donor in HLA-DPB1 mismatches
New test helps guide treatment for bone marrow transplant patients with GVHD
A new test can assist in the treatment of patients with graft-versus-host disease (GVHD), an often life-threatening complication of bone marrow and stem cell transplants.
Test predicts response to treatment for graft-versus-host disease (GVHD)
A new test may reveal which patients will respond to treatment for graft-versus-host disease (GVHD), a serious complication that can arise from stem cell SCT.
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