Ribociclib Shown to Penetrate the Blood-Brain Barrier in Glioblastoma
A phase 0 study of ribociclib in patients with recurrent glioblastoma seeks to inform the feasibility of the use of CDK 4/6 inhibitors for deadly brain tumors.
Glioblastoma
Brain Cancer Treatment Regimens
View detailed drug regimens for the treatment of brain cancer, including treatments such as temozolomide, carboplatin, and methotrexate.
Combining CAR-T and BiTE in Models of Glioblastoma Multiforme
This study involved the engineering of CAR-T cells specific for the EGFRvIII antigen to also secrete bispecific T cell engagers (BiTEs) against wild-type EGFR.
Tumor-treating Fields Useful to Improve Glioblastoma Outcomes
Adverse event rates were similar in both trial groups, though patients treated with TTFields were much more likely to have mild to moderate skin toxicity.
Drug Combination Does Not Extend Glioblastoma Survival
Lomustine plus bevacizumab may increase progression-free, but not overall, survival versus lomustine alone in progressive glioblastoma.
Zika Virus Preferentially Targets Glioblastoma Stem Cells
Researchers have determined that, relative to differentiated tumor progeny or normal neuronal cells, ZIKV preferentially infects and kills GSCs.
Temozolomide With Radiotherapy for Glioblastoma Provides Some Survival Benefit in Elderly
The addition of temozolomide to short-course radiotherapy in elderly patients with glioblastoma was associated with some survival benefit compared with radiotherapy alone.
No Connection Found Between CMV Infection and Aggressive Brain Cancer
A recent analysis of tumor tissue samples from patients with glioblastoma and glial cancer indicate no association between CMV infection and brain cancer.
Anti-malaria Drug Chloroquine May Help Combat Some Brain Tumors
Adding the anti-malaria drug chloroquine to standard therapies may help combat resistance to therapy and also resensitize glioblastoma patients to targeted treatments that had previously stopped working.
Dual Antigen Targeting by CAR T Cells Improves Immunotherapeutic Technique
Chimeric antigen receptor (CAR) T cells may have improved therapeutic potential when they have 2 targets, according to preclinical findings using a mouse model.
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