Combining CAR-T and BiTE in Models of Glioblastoma Multiforme
This study involved the engineering of CAR-T cells specific for the EGFRvIII antigen to also secrete bispecific T cell engagers (BiTEs) against wild-type EGFR.
Diagnosis & Disease Information
Prognostic Significance of Epidermal Growth Factor Receptor Expression in Glioma Patients
[OncoTargets and Therapy] A meta-analysis was conducted to evaluate the effect of abnormal EGFR expression on overall survival (OS) in patients with glioma.
Spherical Shape of New Drug Holds Promise for Bypassing the Blood Brain Barrier and Treating Aggressive Brain Cancer
An investigational drug with a novel spherical nucleic acid structure has the potential to cross the blood-brain barrier to treat glioblastoma multiforme.
Subtype of Glioblastoma Multiforme Responds to Antiangiogenic Chemotherapy
Although previous clinical trials have demonstrated that antiangiogenetic chemotherapy is not effective in GBM, researchers conducted a retrospective of review of perfusion MR images to determine if a phenotypic subtype of GBM may respond to antiangiogenic chemotherapy.
Caregiver Mastery Linked to Patient Survival in Glioblastoma
An analysis of data from caregivers and patients participating in a longitudinal study funded by the National Institutes of Health examines whether caregivers’ anxiety, depressive symptoms, burden, and mastery influence survival for patients with newly diagnosed glioblastoma multiforme.
Medicaid Insurance Linked to Worse Outcomes for Patients With Glioblastoma Multiforme
Insurance status influences overall patient survival for some cancer types, but its impact on glioblastoma multiforme (GBM) survival is well documented. This research study explored the possible impact of insurance on GBM survival.
Extent of Resection Influences Length of Progression-Free Survival in Glioblastoma
Gross total resection to treat glioblastoma multiforme (GBM) showed progression-free survival benefits over subtotal resection and biopsy in a meta-analysis of 37 studies.
Eight Immune Genes Identified As Playing a Role in Glioblastoma
Discovery might eventually lead to better treatment for glioblastoma multiforme
Valproic Acid, Levetiracetam Do Not Improve Survival in Newly Diagnosed GBM
Valproic acid and levetiracetam do not improve survival outcomes in patients with newly diagnosed glioblastoma, according to a recently published study.
Existing Drug May Limit Recurrence and Metastasis of Glioblastoma Multiforme
Researchers identified propentofylline as a drug that could help treat patients with the deadly brain cancer glioblastoma multiforme.
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