New Research Identifies Potential Bladder Cancer Chemotherapy Side Effect
A recent study undertaken sought to examine the effects of chemotherapy on bladder cancer cells and possible connections to later treatment resistance.
Genetics
Outcomes Are Better for HPV16-Associated Oropharyngeal Cancer, but Not for Other HPV Strains
Patients with oropharyngeal tumors that harbor HPV16 have higher 5-year survival and lower recurrence rates than patients with tumors that harbor other HPV strains or are HPV-negative.
Ezh2 Inhibitors May Offer Cure for Chronic Myelogenous Leukemia
Inhibition of the protein Ezh2 causes chronic myelogenous leukemia (CML) stem cells to die. Adding drugs that target this protein to imatinib (Gleevec) or other BCR-ABL blockers could result in a cure for this disease.
Cancer Cell Lines Can Predict Treatment Response, Improve Personalized Therapy
Patient-derived cancer cell lines contain most of the genetic changes found in patients’ tumors and could be used to determine tumor response to treatment, increasing the success rate of new personalized therapies for cancer.
Hybrid Immune Cells Have Antitumor Effects in Early Stage Lung Cancer
A subset of tumor-associated neutrophils (TANs) has hybrid characteristics of both neutrophils and antigen-presenting cells in samples from early stage human lung cancers.
Identifying Smaller ctDNA Fragments Improves Sensitivity of Liquid Biopsy
Circulating tumor DNA (ctDNA) has shorter fragment sizes than DNA fragments from healthy cells that have died, and this may increase the clinical utility of liquid biopsies.
Blood Biomarker Is Predictive of Risk for Colon Cancer Recurrence
Genetic biomarkers from tumor DNA circulating in the bloodstream could indicate the risk for recurrence of colorectal cancer and the efficacy of chemotherapy after surgery.
Gene Expression Alters Bone Marrow Environment in MGUS, Leading to Multiple Myeloma
Researchers discovered that changes in the bone marrow needed for multiple myeloma to grow have already taken hold in patients with MGUS.
Rare Mutations in Immune-Related Genes Linked to Multiple Simultaneous Colorectal Cancer Tumors
Genetic mutations affecting the immune system were identified in patients who develop more than one CRC tumor at the same time, and understanding how these cancers develop could improve therapy targeting.
Epigenetic Regulator of Tumorigenesis Suggests New Strategies Against Breast Cancer
The protein CBX8 uses a previously unknown mechanism to promote the origin of breast tumors, or tumorigenesis, in the most lethal forms of breast cancer, according to new research.
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