New Predisposition Genes for Familial Polycythemia Vera Are Identified
Predisposition genes for familial polycythemia vera were identified via exome sequencing in a Finnish family with 4 patients.
Genetics
Use of Counseling, Surgery Rates Show Limited Physician Knowledge of Breast Cancer Genetic Testing
Limited use of genetic counselors and high rate of double mastectomy in women at average risk with early-stage breast cancer illustrate that understanding of genetic testing results is limited.
Genetic Underpinnings of Splanchnic Vein Thrombosis in Myeloproliferative Neoplasms May Provide New Insights
Risk factors for splanchnic vein thrombosis in patients with myeloproliferative neoplasms are multifactorial, involving both environmental and host genetic factors.
New Gene Mutations Associated with Erdheim-Chester Disease Could Improve Treatment Options
BRAF other MAPK pathway gene mutations associated with Erdheim-Chester disease reveal that ECD is a neoplastic disease.
12 More Genetic Variants Found to Increase Risk for Ovarian Cancer
A team of international researchers identified 12 new genetic variants that increase a woman’s risk of developing ovarian cancer.
Two Infants Achieve Leukemia Remission After Gene Therapy
Two infants with advanced acute lymphoblastic leukemia (ALL) achieved full remission following gene therapy involving modified autologous CAR-T cells.
Study Suggest New Treatment Approaches for High-Risk Pediatric Leukemia
Three specific genetic alterations may help identify pediatric patients with AMKL at high risk who may benefit from allogeneic stem cell transplants.
New Use of an Old Drug Could Address Cancer Metastasis
CDK 4/6 inhibitors, currently approved for the treatment of estrogen-positive breast cancer, were found to inhibit metastasis in triple-negative breast
High Immune Gene Expression Linked to Better Prognosis in TNBC
Researchers assessed the relationship between immune gene expression and genomic complexity in TNBC in a study presented at SABCS 2016.
Men With Genetic Risk of CRC May Lower Risk Via Healthy Lifestyle
Adopting healthy lifestyle can cut 25-year risk for the disease from 29 to 13 percent.
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