Treatment for Hereditary Breast Cancer Not Always Guideline-Concordant
Treatment seems less in line with practice guidelines, particularly for radiation therapy and chemotherapy
Diagnosis & Disease Information
Frequency of Reclassifications of Genetic Testing Results Is Low
A retrospective analysis of genetic testing results at one laboratory reports that reclassifications occurs in approximately one-quarter of tests, resulting in both downgrades and upgrades of variant classifications.
Genetic Link Between Depression and Breast Cancer Remains Unclear
In this study, researchers sought to determine if a genetic predisposition to depression exists in some patients with breast cancer and how to identify it.
Fathers Can Pass Inherited Ovarian Cancer Risk to Daughters
Researchers hypothesize that ovarian cancer may be X-linked and associated genes may be passed from the paternal grandmother via the father’s inherited genetic material.
Oncotype DX Recurrence Score a Potential Marker of Hereditary Breast Cancer
Researchers conducted a review of more than 400 patients with hormone receptor-positive breast cancer to determine if high Oncotype DX RS is associated with a greater likelihood the cancer is hereditary.
Vemurafenib Granted FDA Approval as First Drug to Treat Erdheim-Chester Disease
Indications for vemurafenib are expanded to include BRAF V600 mutation-positive Erdheim-Chester disease, an extremely rare non-Langerhans cell histiocytosis. FDA approval is based on results from the phase 2 VE-BASKET study.
A Review of CDK4/6 Toxicities and Interactions Management in Breast Cancer
CDK4/6 inhibitors, which block the activity of regulatory enzymes, are tolerated fairly well in patients with cancer; however, oncology nurses should be aware of some strategies that minimize their adverse effects.
First Case of Dermatomyositis Associated with Secondary Myelofibrosis Following Polycythemia Vera
A male patient with a history of polycythemia vera that converted to myelofibrosis becomes a first known case of dermatomyositis associated with secondary myelofibrosis.
Use of Aspirin, NSAIDs Correlates with Improved Overall Survival in Colorectal Cancer
Regular use of NSAIDs after diagnosis of colorectal cancer correlated with improved survival in survivors with KRAS wild-type tumors.
Superior Tolerability, Efficacy With Alectinib in Treatment-Naïve ALK-poistive NSCLC
Phase 3 clinical trial results show fewer adverse effects and longer survival with alectinib compared with crizotinib in patients with treatment-naïve ALK-positive NSCLC.
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