Cognitive Function Impacts Oral Cancer Therapy Adherence
Cognitive function is an important factor when considering oral therapy as an option for cancer treatment, particularly for elderly patients with cancer.
Diagnosis & Disease Information
PET-CT Can Inform Decision to Omit Bleomycin in Hodgkin Lymphoma Treatment to Reduce Toxicity
Omitting bleomycin from the treatment regimen for Hodgkin lymphoma in patients with negative findings on an interim PET scan led to a lower incidence of pulmonary toxic effects without significantly lowering treatment efficacy.
Comparative Efficacy and Safety of Axitinib Versus Sorafenib in Metastatic Renal Cell Carcinoma: A Systematic Review and Meta-analysis
[Oncotargets and Therapy] This research evaluates the comparative efficacy and safety of axitinib and sorafenib for the treatment of metastatic renal cell carcinoma.
New Nanoplatform Improves Drug Delivery in Anaplastic Thyroid Cancer
Scientists developed an innovative nanoplatform to more effectively deliver RNA interference to anaplastic thyroid cancer (ATC) sites. ATC is the most aggressive form of thyroid cancer; mortality is almost 100% and median survival is 3 to 5 months.
Nonadherence to Noncancer Medication Schedules Predicts Adherence to Adjuvant Hormone Therapy for Breast Cancer
Patients who do not adhere to their medication schedules for chronic conditions prior to a breast cancer diagnosis were twice as likely to skip oral adjuvant hormonal therapy.
Novel Antibody-Drug Conjugate Bridges Patients With Relapsed ALL to Stem Cell Transplant
In a randomized phase III study of the drug inotuzumab ozogamicin, a statistically significant percentage of patients with ALL whose disease had relapsed following standard therapies, qualified for stem cell transplants after treatment with the drug.
Topical Skin Creams Are Effective in Treatment of Superficial Basal Cell Carcinoma
Results from a clinical trial indicate that 2 topical creams compared favorably to photodynamic therapy for primary, low-risk superficial basal cell carcinoma.
Outcomes Are Not Improved With Pegylated Interferon Alpha-2a vs Interferon Alpha-2a
PEG-IFN did not improve improve outcomes for patients with melanoma compared with IFN. Furthermore, patients receiving PEG-IFN were more likely to discontinue treatment due to toxicity.
Novel Drug Manufacturing Technique Removes Excess Additives, Reduces Serious Allergic Reactions
A breakthrough technique in the manufacture of injectable drugs removed surfactants in an effort to reduce serious allergic reactions and other side effects, making injectable medicines safer.
Modified Thiazole Benzenesulfonamide Demonstrates Anticancer Activity in Melanoma
A newly discovered synthesized drug reduced the viability of melanoma cells without affecting normal cells in cell culture and mouse xenograft models of the disease. The drug, HA15, is a type of thiazole benzenesulfonamide.
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