Resistance and Overcoming Resistance in Breast Cancer
[Breast Cancer: Targets and Therapy] This review focuses on understanding how breast cancer responds to treatment and how resistance develops.
Diagnosis & Disease Information
Intratumor Rotavirus Therapy Has Potential to Overcome Immunotherapy Resistance
In immunocompetent murine models of lymphoma and neuroblastoma, IT rotavirus therapy demonstrated that it can overcome immune checkpoint inhibitor resistance.
Dabrafenib + Trametinib Rechallenge Active in Pretreated Melanoma
Rechallenge with dabrafenib plus trametinib demonstrated antitumor activity in patients who had previously progressed on BRAF inhibitor therapy.
Anti-malaria Drug Chloroquine May Help Combat Some Brain Tumors
Adding the anti-malaria drug chloroquine to standard therapies may help combat resistance to therapy and also resensitize glioblastoma patients to targeted treatments that had previously stopped working.
New Understanding of Mechanisms Revealed in Development of Breast Cancer and Resistance to Treatment
Researchers explore the biologic influences of breast cancer development and resistance to treatment.
New Research Identifies Potential Bladder Cancer Chemotherapy Side Effect
A recent study undertaken sought to examine the effects of chemotherapy on bladder cancer cells and possible connections to later treatment resistance.
Recently Discovered microRNA Controls Response to Oxaliplatin in Colorectal Cancer
Danish researchers identified a microRNA shown to predict whether a patient with colorectal cancer would be resistant to oxaliplatin treatment, a discovery that holds promise of improving both current treatment options and development of future treatment strategies.
Understanding a Molecular Switch Modulating Tumor Metastasis and Chemotherapy Resistance
Dab2 is an endocytic adaptor and tumor suppressor whose expression occurs during the epithelial-mesenchymal transition, which is mediated by TGF-beta. This study sought to understand how Dab2 regulates apoptosis.
T Cells Have the Potential to Reverse Chemotherapy Resistance in Patients With Ovarian Cancer
A new perspective on chemotherapy resistance in ovarian cancer may be a step toward overcoming that resistance. Fibroblasts block chemotherapy, leading to chemotherapy resistance; however, immune system T cells can reverse that resistance.
Hsp90 Inhibition Overcomes Hormone Resistance in Some Aggressive Prostate Cancers
The second-generation hsp90 inhibitor onalespib may be beneficial for men with prostate cancer that no longer responds to androgen deprivation therapy
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