ASTRO Offers Guidance on RT for IDH-Mutant Diffuse Grade 2, 3 Glioma
Guideline recommendations support reduction in volume of brain irradiation while attempting to maximize disease control.
Diagnosis & Disease Information
Emopamil-Binding Protein Inhibitor Designated Orphan Drug for Brain Cancer
DSP-0390 is an inhibitor of emopamil-binding protein, an endoplasmic reticulum membrane protein involved in cholesterol biosynthesis.
High-Dose Methotrexate and Nephrotoxicity Risk in Patients With Hematologic Cancers
The retrospective analysis included 144 patients in three Australian health care facilities with a total of 539 episodes of high-dose methotrexate.
Late Outcomes Support Radiation-Limiting Treatment Strategies for Pediatric Glioma
Use of radiation decreased over time, while use of surgery alone increased.
Survivors of Medulloblastoma Have Greater Risk of Stroke, Severe Hearing Loss
Medulloblastoma survivors had an increased risk of long-term adverse outcomes.
Larotrectinib Produces “Remarkable” Responses in NTRK Fusion-Positive CNS Tumors
The median duration of response was not reached at a median follow-up of 26 months.
Molecular Analysis Refines Diagnosis, Enables Personalized Treatment for Pediatric CNS Tumors
Of the patients who completed follow-up, 60% had a targeted therapy recommendation.
RNA Sequencing Reveals Clinically Relevant Alterations in Pediatric Low-Grade Glioma
RNA sequencing confirmed the alterations most frequently described in low-grade glioma and revealed rare gene fusions.
Assay-Guided Therapy Improves Survival in High-Grade Glioma
Patients who received treatment selected by the ChemoID assay had superior progression-free survival and overall survival.
Risk of Leptomeningeal Metastasis in Melanoma Linked to Anatomic, Surgical Factors
Researchers found that entry into the ventricle space during surgical resection elevated the risk of leptomeningeal disease in patients with melanoma brain metastases.
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