Some Targeted Therapies May Miss the Mark
Ten different drugs continued to kill cancer cells even when their target proteins were removed.
Biomarkers
Serum-Free Light Chain Surge Linked to Tumor Lysis Syndrome in Myeloma
A sudden increase of serum-free light chains was associated with treatment-induced tumor lysis syndrome in multiple myeloma, suggesting a possible risk factor.
Germline Testing Should Be Routinely Conducted in Patients With Metastatic Breast Cancer
High prevalence of pathogenic/likely pathogenic variants supports wider testing.
Quantifying Driver Alterations in BCR-ABL1-Negative Myeloproliferative Neoplasms
A systematic review of studies sought to determine the likelihood of myeloproliferative neoplasm subtypes based on patients’ genetic alterations.
Potential Clinically Useful Prognostic Biomarkers in Triple-negative Breast Cancer: Preliminary Results of a Retrospective Analysis
[Breast Cancer: Targets and Therapy] This research examines possible core biomarkers for triple-negative breast cancer.
Evolution of HER2-Positive Breast Cancer: Yesterday, Today, and Tomorrow
A review of HER2-positive breast cancer, including etiology, diagnosis, and treatments.
Novel Approach Can Improve Both Colorectal Cancer Screening Outcomes and Adherence
Study results presented at the 2018 Gastrointestinal Cancers Symposium demonstrated the sensitivity and specificity of the CMx biomimetic platform, a novel approach to detecting CRC and precancerous lesions that could improve screening rates.
Presence of Protein E6 Predictive of Oropharyngeal Cancer Risk in HPV16-Infected Persons
Protein produced by chronically infected cells in persons with HPV16 infection serves as a biomarker for risk of cancer of the oropharynx.
CTCs Promising as Biomarker to Identify Lung Cancer Recurrence
Prospective pilot study demonstrates accuracy of circulating tumor cells as a biomarker indicating lung cancer recurrence.
Nasal Biomarker in Smokers Could Predict Lung Cancer
Novel diagnostic test determines whether suspicious lung lesions or nodules are malignant disease from a sample obtained via nasal swab.
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