High-Risk Mutations May Underlie Worse Outcomes in Men With MPN, Study Suggests
This study showed that MPN is more aggressive in men vs women and explored whether sex differences in the genomic landscape of MPN could explain this difference.
Biomarkers
Angiogenesis in Hepatocellular Carcinoma; Pathophysiology, Targeted Therapy, and Role of Imaging
[Journal of Hepatocellular Carcinoma] In this review, the authors discuss the use of imaging techniques and radiological biomarkers to monitor treatment response in patients with advanced HCC undergoing antiangiogenic therapy, a key to decisions on whether to continue treatment or initiate second-line therapy.
RBC Count, Erythrocyte Sedimentation Rate May Be Useful Biomarkers of Polycythemia Vera
Although some red blood cell-related parameters used in the diagnosis of PV may be misleading in the setting of iron-deficiency, RBC count may be an effective biomarker for PV when combined with ESR.
Patient Simulation Project in Lung, Breast Cancers Points to Improvements in Quality of Care
Palliative care and end-of-life needs were not addressed for approximately 40% of simulated patients who would have been eligible for this approach.
Some Targeted Therapies May Miss the Mark
Ten different drugs continued to kill cancer cells even when their target proteins were removed.
Serum-Free Light Chain Surge Linked to Tumor Lysis Syndrome in Myeloma
A sudden increase of serum-free light chains was associated with treatment-induced tumor lysis syndrome in multiple myeloma, suggesting a possible risk factor.
Germline Testing Should Be Routinely Conducted in Patients With Metastatic Breast Cancer
High prevalence of pathogenic/likely pathogenic variants supports wider testing.
Quantifying Driver Alterations in BCR-ABL1-Negative Myeloproliferative Neoplasms
A systematic review of studies sought to determine the likelihood of myeloproliferative neoplasm subtypes based on patients’ genetic alterations.
Potential Clinically Useful Prognostic Biomarkers in Triple-negative Breast Cancer: Preliminary Results of a Retrospective Analysis
[Breast Cancer: Targets and Therapy] This research examines possible core biomarkers for triple-negative breast cancer.
Evolution of HER2-Positive Breast Cancer: Yesterday, Today, and Tomorrow
A review of HER2-positive breast cancer, including etiology, diagnosis, and treatments.
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