Avelumab Maintenance: No OS Benefit vs Continued Chemotherapy in HER2-Negative Gastrointestinal Cancers
Fewer treatment-related grade 3 or higher adverse events were reported in the avelumab arm compared with the chemotherapy arm.
Diagnosis & Disease Information
Tumor Size and Stiffness May Be Relevant Biomarkers of Response to ICIs in Hepatocellular Carcinoma
The median change in HCC tumor size between responders and nonresponders was statistically significant.
No Local Control or OS Benefit Seen With RT Dose Escalation in Inoperable Esophageal Cancer
In this study, patients were randomly assigned to receive standard-dose RT or standard-dose RT plus an integrated RT boost to the primary tumor.
Addition of Pegilodecakin to FOLFOX Did Not Improve OS in Metastatic Pancreatic Cancer
Promising results from an earlier-phase study of FOLFOX plus pegilodecakin in metastatic PDAC refractory to gemcitabine provided a rationale for this study.
Addition of PEGPH20 to Frontline Chemotherapy Did Not Improve Clinical Outcomes in Pancreatic Cancer Subgroup
Pegvorhyaluronidase alfa is an enzyme that breaks down hyaluronan, thought to be a contributor to the structure of the tumor microenvironment in some pancreatic cancers.
Prior Exposure to Antibiotics or Antacids Did Not Reduce Immunotherapy Response in Advanced HCC
Researchers hypothesized that because prior studies have demonstrated that common drugs can affect the microbiome, these medications could also impact IO efficacy in HCC.
Study Reveals Differences Between the Genomic Profiles of Primary Tumors and Metastatic Lesions in Intrahepatic Cholangiocarcinoma
Previous genomic profiling studies have identified potentially targetable alterations in IDH1 and FGFR2 in primary tumor specimens of some patients with IHCC.
Older Adults Are Less Likely to Receive Second-Line Therapy for Metastatic Colorectal Cancer, Study Reports
Even though older adults were prescribed second-line therapies less frequently than younger adults, patients had similar overall survival outcomes across age subgroups.
Primary Tumor Resection Prior to Chemotherapy Does Not Improve OS in Patients With Synchronous Metastatic CRC
Synchronous metastatic disease is characterized by the presence of metastatic lesions, in addition to the primary tumor, at diagnosis.
Phase 2 Results: Pembrolizumab Shows Antitumor Activity and a Manageable Safety Profile in Anal Squamous Cell Carcinoma
This single-arm, phase 2 study of pembrolizumab in advanced solid tumor cancers did not limit patient enrollment based on tumor PD-L1 expression level.
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