Existing antibiotic may help fight leukemia
The IV antimicrobial tigecycline, indicated for the treatment of various infections, targets and destroys leukemia stem cells by cutting off the cell’s energy production.
The IV antimicrobial tigecycline, indicated for the treatment of various infections, targets and destroys leukemia stem cells by cutting off the cell’s energy production.
A monoclonal antibody that disrupts the activation of osteoclasts increased bone-metastasis-free (BMF) survival in men with prostate cancer in a recent large trial.
Clinical outcome can be predicted shortly after administration of the HDAC inhibitor entinostat among women with metastatic breast cancer, according to the company that developed the agent.
The FDA has revoked its approval of the breast cancer indication for Avastin (bevacizumab). The anti-angiogenic therapy remains indicated for some colorectal, lung, brain, and kidney cancers.
NSAIDs may be associated with lower colorectal cancer mortality among postmenopausal women, particularly in those who use these agents for longer periods of time before a diagnosis is made.
Combining broccoli with a spicy food that contains the enzyme myrosinase significantly enhances the anticancer properties of each, indicates a recent study.
A poly(ADP-ribose) polymerase (PARP) inhibitor that has shown promising anticancer activity in the presence of BRCA1 or BRCA2 gene mutations also appears to be effective in the treatment of more common, nonhereditary ovarian tumors.
A vasodilator that blocks the activity of a protein called Rho kinase (ROCK) may be effective against difficult-to-treat types of leukemia.
Researchers have designed a new anticancer agent that targets the survival mechanism of cancer cells, according to a report published in the Journal of Biological Chemistry (2010;285(16):9780-9791).