Impact of CYP3A4 pathway
How does the CYP3A4 pathway impact metabolism of the new oral targeted agents in oncology?
Diagnosis & Disease Information
Therapeutic vaccine for brain cancer being studied
A vaccine for people newly diagnosed with glioblastoma multiforme—the most aggressive and highest-grade malignant glioma—is being tested at 20 sites nationwide in a phase II trial.
Bevacizumab delays return of ovarian cancer
The use of bevacizumab (Avastin) improved progression-free survival in women with ovarian cancer, particularly those at high risk for disease progression.
Zoledronic acid continues to improve survival in premenopausal breast cancer
Long-term follow-up data suggest that adjuvant zoledronic acid results in highly significant disease-free and overall survival, mainly in patients with low levels of estrogen.
Ductal delivery of breast drugs may best IV
Compared to standard chemotherapy, administering cancer-fighting agents directly into breast ducts rather than intravenously may be safer and less painful for controlling early breast cancer.
Concurrent anastrozole/fulvestrant could be new first-line breast cancer treatment
Administering anastrozole (Arimidex) and fulvestrant (Faslodex) in combination rather than in sequence extended overall survival by 6 months in women with metastatic breast cancer, researchers reported at the CTRC-AACR San Antonio Breast Cancer Symposium.
Fish oil and a low-fat diet slowed growth of PCa cells
Lowering dietary fat and decreasing the ratio of omega-6 to omega-3 PUFAs reduces the risk of prostate cancer development and progression in men, a recent study in Cancer Prevention Research found.
Everolimus combination improved progression-free survival in neuroendocrine tumors
Progression-free survival improved in patients with advanced neuroendocrine tumors when everolimus rather than placebo was used in combination with octreotide long-acting repeatable.
Diabetes drug helps prevent growth of breast cancer cells
Metformin, a widely used agent in the treatment of type 2 diabetes, stopped a number of natural and man-made chemicals from stimulating the growth of breast cancer cells.
Cisplatin surprise: Drug binds quickly to RNA
Cisplatin binds 20-fold more pervasively to RNA than to DNA, making RNA a potential new drug target for the platinum compound, which is used to fight tumors in nearly 70% of cancers.
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