Angiogenesis Inhibitors (Fact Sheet)
This fact sheet reviews the use of angiogenesis inhibitors.
Diagnosis & Disease Information
The Impact of Histological Types on the Efficacy of Angiogenesis Inhibitors in the Treatment of Advanced NSCLC: A Meta-Analysis of Randomized Controlled Trials
This research assesses the overall efficacy of angiogenesis inhibitor (AI)-containing regimens in the treatment of advanced non-small-cell lung cancer (NSCLC).
Breast cancer metastasis may be tied to cell that regulates blood flow
Scientists believe that targeting blood vessel cells known as pericytes may offer a potential new therapeutic approach for breast and other cancers.
Novel vaccine targets tumor angiogenesis, then creates a secondary immune response
A novel DNA vaccine is being employed to kill cancer, not by attacking tumor cells, but by targeting the blood vessels that keep them alive.
CT data help predict survival in metastatic melanoma
Computerized tomography adds to lactate dehydrogenase (LDH) levels in predicting survival among persons with metastatic melanoma on bevacizumab.
FDA Update – September/October 2012
News from the FDA on bosutinib (Bosulif), ziv-aflibercept (Zaltrap), and everolimus oral suspension tablets (Afinitor Disperz).
Well-known antifungal drug shows promise against cancer
Thiabendazole, an antifungal drug in clinical use for 40 years, inhibits angiogenesis, slows tumor growth, and reduces vascular density of tumors.
VEGF blockade: Optimizing chemotherapy drug uptake
New research is showing that sequence and timing have significant impact on the efficacy of therapeutic regimens that include bevacizumab.
Antiangiogenics could be effective against new ovarian cancer subtype
A newly identified subtype of ovarian cancer that builds its own blood vessels may be vulnerable to agents that block blood vessel formation.
Experimental agent slows progression of colorectal cancer
The investigational drug regorafenib conferred a statistically significant survival benefit in patients with metastatic colorectal cancer in whom no standard therapy was effective.
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