Clonal Hematopoiesis in Hematologic Malignancies, Bone Marrow Failure Syndromes, and Stem Cell Clones
Recent studies have better elucidated the link between clonal hematopoiesis and hematologic malignancies.
Anemias
FDA Approves Reblozyl for Anemia in Patients With Myelodysplastic Syndromes
The FDA has approved Reblozyl® (luspatercept–aamt; Bristol-Myers Squibb and Acceleron) for the treatment of anemia in adults with lower-risk myelodysplastic syndromes.
Interim Phase 2 Analysis of Luspatercept in Treatment of Myelofibrosis-Associated Anemia
Data from an ongoing trial of luspatercept, an erythroid maturation agent, in patients with myelofibrosis and anemia shows promise of clinically significant activity with low level of grade 3/4 adverse effects.
Managing Anemia Associated With Olaparib for Relapsed Ovarian Cancer
What are the recommendations for managing anemia in patients receiving olaparib?
Toward the Development of a Risk Stratification Scheme for Identifying Patients at Risk of Severe Chemotherapy-Induced Anemia
Less than 10% of patients developing severe chemotherapy-induced anemia did not have any of the identified potential patient-related risk factors.
Risk for Colon Cancer, Osteogenic Sarcoma Higher With Presence of Diamond-Blackfan Anemia
Researchers reviewed cancer incidence in patients with Diamond-Blackfan anemia.
Anemia in patients with MDS
Managing anemia in patients with myelodysplastic syndrome (MDS) is complex. When are erythroid growth factors used as primary treatment?
Lab tests for anemic patients
In following patients with anemia, what do the lab values for iron, ferritin, transferrin, and TIBC (total iron binding capacity) tell me?
Epoetin alfa reduces anemia but raises clot risk in breast cancer
Adding the ESA epoetin alfa to the chemotherapy regimen for high-risk breast cancer improved hemoglobin levels for patients, but it also resulted in increased thrombosis.
Chemotherapy nerve damage stops regrowth of blood stem cells
Chemotherapy-induced nerve injury in the bone marrow is what impairs the regeneration of hematopoietic stem cells, leading to anemia.
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