Skin Cancer

Obesity, Male Gender May Improve Survival Outcomes with Targeted and Immunotherapy in Melanoma

Obesity, Male Gender May Improve Survival Outcomes with Targeted and Immunotherapy in Melanoma

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A retrospective study evaluated the relationship of BMI with survival outcomes among patients with metastatic melanoma who received targeted therapy, immunotherapy, or chemotherapy.

FDA Upgrades Nivolumab to Regular Approval for Adjuvant Treatment of Advanced Melanoma

FDA Upgrades Nivolumab to Regular Approval for Adjuvant Treatment of Advanced Melanoma

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The FDA granted approval for nivolumab for adjuvant treatment of some patients with melanoma, based on the results of the CHECKMATE-238 study.

Potential for Metastatic Melanoma Cure Seen in High CR Rate With Pembrolizumab

Potential for Metastatic Melanoma Cure Seen in High CR Rate With Pembrolizumab

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Baseline tumor size and PD-L1 status were independently associated with the likelihood of a complete response.

Distinct Patterns of Shiny White Streaks Strong Indicator of Melanoma

Distinct Patterns of Shiny White Streaks Strong Indicator of Melanoma

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Patients presenting with lesions with shiny white streaks on dermoscopy should undergo biopsy for possible melanoma.

Adherence to Skin Cancer Screening Guidelines Beneficial in Management SCC in SOTRs

Adherence to Skin Cancer Screening Guidelines Beneficial in Management SCC in SOTRs

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Transplant recipients developed squamous cell carcinomas that did not appear to behave more aggressively than those that developed in the immunocompetent group.

Fluorouracil Associated With Reduced Surgery for Squamous Cell Carcinoma

Fluorouracil Associated With Reduced Surgery for Squamous Cell Carcinoma

A reduced risk of squamous cell carcinoma, but not basal cell carcinoma, was observed for one year in at-risk individuals treated with fluorouracil.

Atopic Dermatitis Linked to Increased Risk of Skin Cancer

Atopic Dermatitis Linked to Increased Risk of Skin Cancer

Individuals with a history of atopic dermatitis have a higher risk of squamous cell carcinoma development, research indicates.

No Increased Risk for Melanoma in Patients With MM

No Increased Risk for Melanoma in Patients With MM

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An increased prevalence of melanoma has been observed in patients with various immunocompromised conditions.

Researchers Find No Link Between Acne and Malignant Melanoma in Men

Researchers Find No Link Between Acne and Malignant Melanoma in Men

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Individuals categorized as overweight or obese had a significantly increased risk for malignant melanoma.

Survival Benefit in Advanced Melanoma With Pembrolizumab Versus Ipilimumab

Survival Benefit in Advanced Melanoma With Pembrolizumab Versus Ipilimumab

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Fifty-five percent of patients treated with pembrolizumab survived through 24-months compared with 43% of patients treated with ipilimumab.

Challenging the Standard of Care in Advanced Melanoma: Focus on Pembrolizumab

Challenging the Standard of Care in Advanced Melanoma: Focus on Pembrolizumab

[Cancer Management and Research] This study examines the advances that pembrolizumab has made in melanoma and upcoming research that may further improve melanoma treatment.

Is This the End of Cytotoxic Chemotherapy in Merkel Cell Carcinoma?

Is This the End of Cytotoxic Chemotherapy in Merkel Cell Carcinoma?

[OncoTargets and Therapy] A review of the role of chemotherapy in the treatment of Merkel cell carcinoma in view of the recent FDA approval of the PD-L1 antibody avelumab and limited and controversial data on the efficacy of chemotherapy in this disease.

Overall Survival in Advanced Melanoma Improved With Nivolumab, Ipilimumab Combination

Overall Survival in Advanced Melanoma Improved With Nivolumab, Ipilimumab Combination

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Overall survival was significantly prolonged in patients with advanced melanoma who were treated with nivolumab plus ipilimumab compared with either drug alone, according to results from the Checkmate 067 study.

Skin Cancer Prevention Strategies Lacking in Work Settings

Skin Cancer Prevention Strategies Lacking in Work Settings

High occupational UV exposure tied to two-fold increase in skin cancer risk, but prevention strategies in work environments are often underutilized.

Awareness of Genomic Risk for Melanoma May Increase Conversations With Family, Health Care Providers

Awareness of Genomic Risk for Melanoma May Increase Conversations With Family, Health Care Providers

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Awareness of personal genetic risk for melanoma may prompt patients to discuss cancer risk with family and health care professionals, and make lifestyle changes.

Risk of Nonmelanoma Skin Cancers Increased With Alcohol Consumption

Risk of Nonmelanoma Skin Cancers Increased With Alcohol Consumption

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Researchers found that an association between alcohol consumption and nonmelanoma skin cancers may be dose-dependent. This risk includes basal cell carcinoma and cutaneous squamous cell carcinoma.

FDA Expands Ipilimumab Indication to Include Pediatric Unresectable or Metastatic Melanoma

FDA Expands Ipilimumab Indication to Include Pediatric Unresectable or Metastatic Melanoma

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The FDA approved the indication expansion for ipilimumab based on evidence from 2 clinical trials evaluating its safety and efficacy in pediatric patients.

Adjuvant Bevacizumab Does Not Increase Survival in High-Risk Melanoma

Adjuvant Bevacizumab Does Not Increase Survival in High-Risk Melanoma

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Five-year survival rate found similar to observation despite a significant improvement in disease-free interval.

Carvedilol, Some Beta Blockers Prevent UVB-induced Skin Cancer

Carvedilol, Some Beta Blockers Prevent UVB-induced Skin Cancer

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A common beta blocker, carvedilol, is found to have preventive properties against the sun-induced cell damage that leads to skin cancer.

Noninvasive 2-Gene Test Helps Distinguish Melanoma From Nonmelanoma

Noninvasive 2-Gene Test Helps Distinguish Melanoma From Nonmelanoma

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Two-gene pigmented lesion test classifies skin lesions as melanoma or nonmelanoma, helping with diagnostic challenges faced with the visual image and pattern recognition approach.

Assessment of Melanoma Screening Practices Produces Data-Driven, Risk-Based Guidelines

Assessment of Melanoma Screening Practices Produces Data-Driven, Risk-Based Guidelines

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Dermatologist assessment of screening practices addresses the lack of a national consensus on screening guidelines for melanoma.

Psoriasis May Increase Risk of Melanoma and Hematologic Cancers

Psoriasis May Increase Risk of Melanoma and Hematologic Cancers

Patients with psoriasis had 1.53 times greater risk of developing a malignancy, regardless of the type of psoriasis therapy they are receiving.

Kinase Inhibitors: Managing Adverse Effects in the Treatment of Metastatic Melanoma

Kinase Inhibitors: Managing Adverse Effects in the Treatment of Metastatic Melanoma

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Despite their efficacy in metastatic melanoma, KIs include risk of serious side effects in patients. This overview explains the effects and management recommendations for 4 agents used to treat metastatic melanoma.

Dabrafenib + Trametinib Rechallenge Active in Pretreated Melanoma

Dabrafenib + Trametinib Rechallenge Active in Pretreated Melanoma

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Rechallenge with dabrafenib plus trametinib demonstrated antitumor activity in patients who had previously progressed on BRAF inhibitor therapy.

Antidiabetes Drug Holds Promise as Adjuvant Therapy for Older Patients with Melanoma

Antidiabetes Drug Holds Promise as Adjuvant Therapy for Older Patients with Melanoma

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Rosiglitazone has potential for older patients with melanoma who develop resistance to targeted therapies.

Indoor Tanning Costs United States Millions of Dollars in Health Care Costs

Indoor Tanning Costs United States Millions of Dollars in Health Care Costs

Skin cancers from ultraviolet light in tanning devices totaled $343.1 million in 2015 alone, researchers say.

Cost-Effectiveness of Immunotherapy for Advanced Melanoma Evaluated

Cost-Effectiveness of Immunotherapy for Advanced Melanoma Evaluated

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Researchers sought to conduct a cost-effectiveness analysis of immunotherapy for patients with advanced melanoma.

Trends in Behaviors, Medical Practice Indicate Mortality From Melanoma Will Decline

Trends in Behaviors, Medical Practice Indicate Mortality From Melanoma Will Decline

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Using statistical models, predictions were made for death rates from melanoma in 3 three countries and based on availability of a treatment.

Computer 'Deep Learning' Algorithm Matches Dermatologists at Classifying Melanomas

Computer 'Deep Learning' Algorithm Matches Dermatologists at Classifying Melanomas

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Researchers compared the ability of an artificial-intelligence algorithm to recognize and classify skin cancers with the clinical evaluations of dermatologists.

IFN Induction No Better Than Observation for Intermediate-risk Melanoma

IFN Induction No Better Than Observation for Intermediate-risk Melanoma

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Induction therapy with intravenous interferon α-2b appeared to be no better than observation alone for the management of patients with intermediate-risk melanoma.

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