Risk Assessment

Cardiotoxicity Risk Greater in Blacks With Breast Cancer Receiving HER2 Therapies

Cardiotoxicity Risk Greater in Blacks With Breast Cancer Receiving HER2 Therapies

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Retrospective study examines the association between risk of cardiotoxicity and race in women with breast cancer receiving chemotherapy and at least 1 year of HER2-targeted therapy.

Distress, Neuroticism Predict Long-term Emotional Distress After Cancer Diagnosis

Distress, Neuroticism Predict Long-term Emotional Distress After Cancer Diagnosis

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A literature sought to identify which signs and symptoms in patients with new cancer diagnoses indicate a greater likelihood for long-term emotional distress.

Arterial Thrombotic Events Associated With First-line Nilotinib for CML in Older Adults

Arterial Thrombotic Events Associated With First-line Nilotinib for CML in Older Adults

A retrospective analysis of patients with CML determined prevalence of arterial thrombotic events in those receiving nilotinib as first-line treatment and prevalence by patient age. Data were presented at ASH 2017.

Risk of Falls, Fractures Greater Among Elderly Patients with Cancer

Risk of Falls, Fractures Greater Among Elderly Patients with Cancer

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Researchers conducted a geriatric assessment of 304 patients with cancer, then followed them in a 2-year study to determine the risk of fractures and falls in older patients.

Oncotype DX Recurrence Score a Potential Marker of Hereditary Breast Cancer

Oncotype DX Recurrence Score a Potential Marker of Hereditary Breast Cancer

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Researchers conducted a review of more than 400 patients with hormone receptor-positive breast cancer to determine if high Oncotype DX RS is associated with a greater likelihood the cancer is hereditary.

Refined Equation May Obviate Oncotype DX in Breast Cancer Treatment Decisions

Refined Equation May Obviate Oncotype DX in Breast Cancer Treatment Decisions

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Research presented at SABCS 2017 demonstrated the effect of refining the linear predictor for determining which patients with breast cancer would potentially benefit from adjuvant chemotherapy.

Compound in Teas, Peas, Soybeans May Increases Prostate Cancer Risk

Compound in Teas, Peas, Soybeans May Increases Prostate Cancer Risk

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An analysis of an intervention arm of the PLCO Cancer Screening Trial evaluated the risk of prostate cancer relative to dietary consumption of isoflavones, a dietary compound found in some plant foods.

Cause of Death More Likely to Be Lung Cancer Than AIDS in Smokers With HIV

Cause of Death More Likely to Be Lung Cancer Than AIDS in Smokers With HIV

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Populating a microsimulation of model of HIV disease, researchers investigated the the likelihood of lung cancer-related morbidity and mortality among patients with HIV who smoke, based on smoking intensity.

Daily Aspirin Reduced Risk of HBV-Related Hepatocellular Carcinoma

Daily Aspirin Reduced Risk of HBV-Related Hepatocellular Carcinoma

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Study presented at the AASLD The Liver Meeting 2017 demonstrated the effect of regular aspirin use on risk of hepatocellular carcinoma in patients with chronic HBV.

PHQ-9 and HADS-D May be Limited in Assessment of MDD in Patients With Cancer

PHQ-9 and HADS-D May be Limited in Assessment of MDD in Patients With Cancer

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Results of a recent study found that the effectiveness of the 9-item Patient Health Questionnaire (PHQ-9) and the Hospital Anxiety and Depression Scale (HADS-D) in screening for major depressive disorder (MDD) in patients with cancer was limited compared to the standardized diagnostic interview.

Cancer Risks for BRCA1/2 Mutation Carriers Determined by Age, Family History, Mutation Location

Cancer Risks for BRCA1/2 Mutation Carriers Determined by Age, Family History, Mutation Location

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Risk assessment study for carriers of the BRCA1/2 mutation identified the factors that influence their risk of developing breast cancer, ovarian cancer, or contralateral breast cancer.

Aspirin Use May Lower Breast Cancer Risk in Women with Diabetes

Aspirin Use May Lower Breast Cancer Risk in Women with Diabetes

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Regular aspirin use is associated with a lower risk of breast cancer among women with diabetes, a recent study from Taiwan has shown.

JAK2 Mutation, Leukocytosis Are Predictive Factors of Thrombosis in Essential Thrombocythemia

JAK2 Mutation, Leukocytosis Are Predictive Factors of Thrombosis in Essential Thrombocythemia

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Presence of JAK2 mutation and leukocytosis are strong predictors for thromboembolic events in patients with essential thrombocythemia (ET).

New Predisposition Genes for Familial Polycythemia Vera Are Identified

New Predisposition Genes for Familial Polycythemia Vera Are Identified

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Predisposition genes for familial polycythemia vera were identified via exome sequencing in a Finnish family with 4 patients.

Distress Management Tool Gets an Update, Patient Version

Distress Management Tool Gets an Update, Patient Version

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A review of the updated NCCN Guidelines is presented with a look at the newly published Guideline for Patients.

Use of Counseling, Surgery Rates Show Limited Physician Knowledge of Breast Cancer Genetic Testing

Use of Counseling, Surgery Rates Show Limited Physician Knowledge of Breast Cancer Genetic Testing

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Limited use of genetic counselors and high rate of double mastectomy in women at average risk with early-stage breast cancer illustrate that understanding of genetic testing results is limited.

Recommendations Against Contralateral Prophylactic Mastectomy Not Tied to Patient Satisfaction

Recommendations Against Contralateral Prophylactic Mastectomy Not Tied to Patient Satisfaction

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Study finds patients are not more likely to report dissatisfaction, seek a second opinion, or change doctors due to physician recommendations against CPM.

Trends in BRCA Mutation Testing Shifting Toward Unaffected Women

Trends in BRCA Mutation Testing Shifting Toward Unaffected Women

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Genetic testing for BRCA gene mutation is increasingly undertaken by women unaffected by breast and/or ovarian cancers.

Risk of Second Cancers Increased in Hodgkin Lymphoma Survivors

Risk of Second Cancers Increased in Hodgkin Lymphoma Survivors

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Hodgkin lymphoma survivors are at higher risk of second cancers, and that risk is even higher in those with a first-degree relative with cancer.

Lifestyle Choices Have Greater Influence on Colon and Rectal Cancer Risk

Lifestyle Choices Have Greater Influence on Colon and Rectal Cancer Risk

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Predictive risk model shows that lifestyle choices have a greater influence on risk for colorectal cancer than does genetic factors.

Comorbidities May Predict Non-Home Discharge After Hysterectomy

Comorbidities May Predict Non-Home Discharge After Hysterectomy

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Presence of 1 risk factor or 2 or more risk factors is associated with non-home discharge after hysterectomy for gynecologic malignancy.

Annual Screening of High-Risk Smokers Only More Cost-effective Than Current Methods

Annual Screening of High-Risk Smokers Only More Cost-effective Than Current Methods

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Annual lung cancer screening of only high-risk smokers more cost-effective than current methods.

Inflammatory Cytokine Levels Increase Breast Tissue Density, Cancer Risk

Inflammatory Cytokine Levels Increase Breast Tissue Density, Cancer Risk

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Discovered link between inflammation and overexpression of CCL2 hints at potential of anti-inflammatory medications as a breast cancer preventive in women with dense-tissue breasts.

Recurrence Score Appears To Be Driving Personalized Treatment for Breast Cancer

Recurrence Score Appears To Be Driving Personalized Treatment for Breast Cancer

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The recurrence score assay stratifies early stage, estrogen receptor-positive breast cancer by recurrence risk. This study assessed how clinicians use the recurrence score to recommend adjuvant systemic therapy or patients' experiences with testing decision-making.

Socioeconomic Status Inversely Related to Risk for Ovarian Cancer in African American Women

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Risk of ovarian cancer is higher in African American women with lower socioeconomic status, the opposite of trends seen in breast cancer.

Prophylactic Gynecologic Resections Increase Risk for Aggressive Uterine Cancer in BRCA Gene Mutation Carriers

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Women who carry the BRCA1 mutation are at increased risk for serous/serous-like endometrial carcinoma after risk-reducing salpingo-oophorectomy. Yet uncertainty exists over the need to perform a full hysterectomy in these women.

Sleep Disorders in Cancer Radiation Therapy: Little Understood, Often Undetected — and Important

Sleep Disorders in Cancer Radiation Therapy: Little Understood, Often Undetected — and Important

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Sleep patterns and habits should be a part of oncology nurses' routine patient assessment, as sleep disorders can be a significant challenge for cancer patients undergoing radiation therapy.

Baseline PSA Levels in Midlife Could Predict Risk of Lethal Prostate Cancer

Baseline PSA Levels in Midlife Could Predict Risk of Lethal Prostate Cancer

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Screening PSA levels at midlife could identify men who are at greater risk of developing prostate cancer later in life and who should be monitored more closely.

Biochemical Marker Is a Better Predictor of Adverse Effects in Patients with Non-small Cell Lung Cancer

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Albumin concentration with an established cutoff point is proven a better predictor of both chemotherapy toxicity and survival in patients with advanced lung cancer.

Prognostic Index Will Improve Clinical Practice Management of Patients With CLL and in Clinical Trials

Prognostic Index Will Improve Clinical Practice Management of Patients With CLL and in Clinical Trials

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An international consortium devised an international prognostic index for chronic lymphocytic leukemia (CLL-IPI) that combines genetic, biochemical, and clinical parameters into a prognostic model to enable more targeted management of patients with CLL.

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