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RETROVIR IV
Viral infections
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Drug Name:

RETROVIR IV Rx

Generic Name and Formulations:
Zidovudine 10mg/mL; for IV infusion after dilution; preservative-free.

Company:
ViiV Healthcare

Therapeutic Use:

Indications for RETROVIR IV:

HIV-1 infection, in combination with other antiretroviral agents. Prevention of maternal-fetal HIV-1 transmission.

Adult:

Give by IV infusion over 1hr; use only until oral therapy can be given. 1mg/kg every 4hrs. Renal impairment (CrCL <15mL/min) or on dialysis: 1mg/kg every 6–8hrs. Prevention of maternal-fetal HIV or vertical transmission, severe anemia and/or neutropenia: see full labeling.

Children:

Vertical transmission: see full labeling.

Boxed Warning:

Hematological toxicity. Myopathy. Lactic acidosis and severe hepatomegaly with steatosis.

Warnings/Precautions:

Risk of hematologic toxicity/bone marrow suppression; monitor CBCs esp. in advanced HIV-1 disease; interrupt dose if anemia or neutropenia occurs. Myopathy with prolonged use. Suspend if lactic acidosis or pronounced hepatotoxicity (eg, hepatomegaly, steatosis) occurs. Monitor for lipoatrophy; use alternatives if suspected. Severe renal impairment: reduce dose (see Adult). Hepatic impairment or cirrhosis: monitor for hematologic toxicity. Latex allergy (IV). Women. Obesity. Elderly. Pregnancy. Nursing mothers: not recommended.

See Also:

Zidovudine Tablets

RETROVIR CAPSULES

RETROVIR SYRUP

Pharmacological Class:

Nucleoside analogue (reverse transcriptase inhibitor).

Interactions:

Avoid concomitant stavudine, doxorubicin, nucleoside analogues (eg, ribavirin). Increased hematologic toxicity with ganciclovir, interferon alpha, ribavirin, other bone marrow suppressants or cytotoxic drugs. Monitor for treatment-associated toxicities (eg, hepatic decompensation) with interferon alpha with or without ribavirin.

Adverse Reactions:

Headache, malaise, nausea, vomiting, anorexia; neutropenia, anemia, myopathy, lactic acidosis, severe hepatomegaly with steatosis, immune reconstitution syndrome, pancreatitis, lipoatrophy. Children: also fever, cough.

Generic Availability:

YES

How Supplied:

Tabs—contact supplier; Caps—100; Syrup—240mL; IV (20mL/vial)—1, 5

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