Research

The Effect of Intravenous Hydration Strategy on Plasma Methotrexate Clearance During Intravenous High-dose Methotrexate Administration in Pediatric Oncology Patients

The Effect of Intravenous Hydration Strategy on Plasma Methotrexate Clearance During Intravenous High-dose Methotrexate Administration in Pediatric Oncology Patients

[Cancer Management and Research] Researchers sought to determine the effect of intravenous hydration on plasma methotrexate clearance on pediatric oncology patients receiving HD-MTX for ALL, NHL, or osteosarcoma.

The Efficacy and Safety of Apatinib for Refractory Malignancies: A Review and Meta-analysis

The Efficacy and Safety of Apatinib for Refractory Malignancies: A Review and Meta-analysis

[OncoTargets and Therapy] A meta-analysis sought to support the efficacy and safety of apatinib in the treatment of solid tumors that was previously reported in previous studies.

Predictive Role of Skin Rash in Advanced Pancreatic Cancer Patients Treated With Gemcitabine Plus Erlotinib: A Systematic Review and Meta-analysis

Predictive Role of Skin Rash in Advanced Pancreatic Cancer Patients Treated With Gemcitabine Plus Erlotinib: A Systematic Review and Meta-analysis

[OncoTargets and Therapy] In this systematic review and meta-analysis, researchers sought to determine the predictive value of skin rash in patients with advanced pancreatic cancer treated with gemcitabine plus erlotinib.

Hypofractionated Radiotherapy After Conservative Surgery May Increase Low-intermediate Grade Late Fibrosis in Breast Cancer Patients

Hypofractionated Radiotherapy After Conservative Surgery May Increase Low-intermediate Grade Late Fibrosis in Breast Cancer Patients

[Breast Cancer: Targets and Therapy] Researchers sought to determine the incidence of subcutaneous side effects in patients with early-stage breast cancer treated with AHF-RT vs standard fractionated RT after breast conserving surgery.

Seeking an Explanation for the Lack of Research Focused in Pediatric Oncology Therapeutics

Seeking an Explanation for the Lack of Research Focused in Pediatric Oncology Therapeutics

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Researchers sought an explanation for the paucity of research, drug development, and clinical trials focusing specifically on cancer in pediatric populations.

Treatment Strategies and Predicting Prognoses in Elderly Patients With Breast Cancer

Treatment Strategies and Predicting Prognoses in Elderly Patients With Breast Cancer

[Cancer Management and Research] Data from a total of 16,998 patients with breast cancer included in the SEER database were evaluated to determine the prognosis of various treatment options for elderly patients.

Delphi Panel Presents Recommendations for Expanding Role of Patients in Research

Delphi Panel Presents Recommendations for Expanding Role of Patients in Research

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A Delphi panel developed recommendations for integrating patients, as well as caregivers and advocate, a greater role in medical research while maintaining scientific integrity of studies.

Anticancer and Cardio-protective Effects of Liposomal Doxorubicin in the Treatment of Breast Cancer

Anticancer and Cardio-protective Effects of Liposomal Doxorubicin in the Treatment of Breast Cancer

[Breast Cancer: Targets and Therapy] This research examines the mechanism of action of L-DOX and its most common side effects and highlight results of its use in clinical trials for the treatment of BC as single agent and in combination with other commonly used chemotherapeutics.

Prophylactic Cranial Irradiation in Small-Cell Lung Cancer: Update on Patient Selection, Efficacy and Outcomes

Prophylactic Cranial Irradiation in Small-Cell Lung Cancer: Update on Patient Selection, Efficacy and Outcomes

[Lung Cancer: Targets and Therapy] This review presents a summary and update of the latest evidence for patient selection, efficacy and outcome of primary treatment, prophylactic cranial irradiation (PCI) in the treatment of patients with SCLC.

American Association for Cancer Research Releases Its 2018 Annual Report

American Association for Cancer Research Releases Its 2018 Annual Report

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In its 2018 annual report, the AACR highlights the advances, challenges, and needs of federally funded research on the prevention, detection, diagnosis, and treatment of cancer.

Current Status and Dilemma of Second-line Treatment in Advanced Pancreatic Cancer: Is There a Silver Lining?

Current Status and Dilemma of Second-line Treatment in Advanced Pancreatic Cancer: Is There a Silver Lining?

[OncoTargets and Therapy] Although first-line therapy is effective, relapse is common; but many patients are good candidates for second-line therapy. This report reviews current published data on second-line therapies for advanced pancreatic cancer.

Long-term Survival Effect of the Interval Between Mastectomy and Radiotherapy in Locally Advanced Breast Cancer

Long-term Survival Effect of the Interval Between Mastectomy and Radiotherapy in Locally Advanced Breast Cancer

[Cancer Management and Research] Retrospective study investigates the effect of radiotherapy on long-term survival in patients who underwent mastectomy for breast cancer at various time intervals.

The Efficacy and Tolerance of High Pressure Oxygen Combined With Chemotherapy in Postoperative Patients With Advanced Gastric Cancer

The Efficacy and Tolerance of High Pressure Oxygen Combined With Chemotherapy in Postoperative Patients With Advanced Gastric Cancer

[Translational Cancer Research] In this research, a combination of gastric cancer postoperative with hyperbaric oxygen therapy to explore the clinical application in postoperative chemotherapy for advanced gastric cancer.

Hepatocellular Cancer Pain: Impact and Management Challenges

Hepatocellular Cancer Pain: Impact and Management Challenges

[Journal of Hepatocellular Carcinoma] A review of the manifestations, treatments, and challenges associated with hepatocellular cancer pain.

New PDL1 Inhibitors for Non-small Cell Lung Cancer: Focus on Pembrolizumab

New PDL1 Inhibitors for Non-small Cell Lung Cancer: Focus on Pembrolizumab

[OncoTargets and Therapy] Evidence increasingly suggests that pembrolizumab has a significant role in first- and second-line therapy for NSCLC. This review presents the results of previous and ongoing studies and discusses biomarkers that can potentially identify eligible candidates for treatment with the PD-L1 inhibitor.

Updates on the Clinical Diagnosis and Management of Ocular Sebaceous Carcinoma: a Brief Review of the Literature

Updates on the Clinical Diagnosis and Management of Ocular Sebaceous Carcinoma: a Brief Review of the Literature

[OncoTargets and Therapy] Disease specifics, demographics, clinical presentation, and pathology, plus diagnosis and management of ocular SC are highlighted and discussed, including recent advances in management of this aggressive malignancy.

Cancer Risk Assessment in Modern Radiotherapy Workflow With Medical Big Data

Cancer Risk Assessment in Modern Radiotherapy Workflow With Medical Big Data

[Cancer Management and Research] A review of the background and current challenges in 4 key areas of radiotherapy are presented, plus potential future options for creating safe and effective strategies in radiotherapy.

Anxiety Not Relieved With Handholding, Stress Ball Use During Skin Cancer Excision

Anxiety Not Relieved With Handholding, Stress Ball Use During Skin Cancer Excision

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Most dermatologic procedures are performed with local anesthesia only. In this study, researchers sought to determine if hand-holding or squeezing a stress ball could ease patients' anxiety during skin excision procedures.

Breath Analysis May Be an Effective Diagnostic for Pancreatic Cancer

Breath Analysis May Be an Effective Diagnostic for Pancreatic Cancer

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Seeking to determine if breath tests could be used to diagnose pancreatic cancer, researchers identified breath volatile organic compounds (VOCs) that may indicate presence of the disease.

Decreased Hepatocellular Carcinoma Tumor Burden With the Achievement of Hepatitis C Virus Sustained Virologic Response: Unlocking the Potential of T-cell-mediated Immunosurveillance

Decreased Hepatocellular Carcinoma Tumor Burden With the Achievement of Hepatitis C Virus Sustained Virologic Response: Unlocking the Potential of T-cell-mediated Immunosurveillance

[Journal of Hepatocellular Carcinoma] In this case series, the authors present procedure and treatment specifics for 2 patients with HCV who developed HCC, and discuss the potential role of DAA therapy and immunosurveillance.

Combined Microwave Ablation and Minimally Invasive Open Decompression for the Management of Thoracic Metastasis in Breast Cancer

Combined Microwave Ablation and Minimally Invasive Open Decompression for the Management of Thoracic Metastasis in Breast Cancer

[Cancer Management and Research] An investigation into the efficacy of microwave ablation and minimally invasive open decompression treatment for breast cancer with thoracic metastases.

Younger Patients, Higher Costs: The Changing Demographics of Cancer

Younger Patients, Higher Costs: The Changing Demographics of Cancer

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This overview provides a snapshot of the shift in cancer care costs and age of patients, reviewing the 4 most commonly diagnosed cancers.

High BMI Among Premenopausal Women May Improve Risk for Breast Cancer

High BMI Among Premenopausal Women May Improve Risk for Breast Cancer

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Researchers report on a study to determine the relationship between BMI and risk for breast cancer among younger women, particularly those 18 to 24 years old.

Interim Data Shows Romiplostim May Lead to Positive Long-Term Response in Pediatric ITP

Interim Data Shows Romiplostim May Lead to Positive Long-Term Response in Pediatric ITP

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In a poster presentation at the 23rd Congress of EHA, researchers described a study of the efficacy of romiplastim in achieving a platelet response in pediatric patients with immune thrombocytopenia.

Prognostic Factors for Survival Among Patients With Primary Bone Sarcomas of Small Bones

Prognostic Factors for Survival Among Patients With Primary Bone Sarcomas of Small Bones

[Cancer Management and Research] The prognostic values of overall survival and cancer-specific survival for bone sarcomas of the hands or feet were assessed using Cox proportional hazards regression model with univariate and multivariate analyses.

Andrographolide Potentiates the Antitumor Effect of Topotecan in Acute Myeloid Leukemia Cells Through an Intrinsic Apoptotic Pathway

Andrographolide Potentiates the Antitumor Effect of Topotecan in Acute Myeloid Leukemia Cells Through an Intrinsic Apoptotic Pathway

[Cancer Management and Research] In this study, researchers explored the potential of andrographolide and topotecan, separately and together, in the in vitro treatment of the U937 acute myeloid leukemic cell line.

Are Ovarian Cancer Stem Cells the Target for Innovative Immunotherapy?

Are Ovarian Cancer Stem Cells the Target for Innovative Immunotherapy?

[OncoTargets and Therapy] In a review of cancer stem cells (CSCs)/ovarian cancer stem cells (OCSCs), researchers discuss the implications of immunotherapy development based on studying cancer evolution by CSCs, and targeting OCSC surface markers to develop CAR-T immunotherapy.

Cancer in Children and Adolescents (Fact Sheet)

Cancer in Children and Adolescents (Fact Sheet)

This fact sheet reviews cancer in adolescents and children, including possible causes, treatment, and the general outlook for childhood cancers.

Response to Rapamycin Analogs but not PD-1 Inhibitors in PTEN-mutated Metastatic Non-small Cell Lung Cancer With High Tumor Mutational Burden

Response to Rapamycin Analogs but not PD-1 Inhibitors in PTEN-mutated Metastatic Non-small Cell Lung Cancer With High Tumor Mutational Burden

[Lung Cancer: Targets and Therapy] This case study demonstrates that genomic profiling may still benefit patients who fail checkpoint inhibitor therapy despite having high tumor mutational burden and PD-L1 positivity.

Multiple Treatment Modalities for Brain Metastasis in Patients With EGFR-mutant Non-small Cell Lung Cancer

Multiple Treatment Modalities for Brain Metastasis in Patients With EGFR-mutant Non-small Cell Lung Cancer

[OncoTargets and Therapy] Management of brain metastases in patients with EGFR-mutant NSCLC is controversial. In this study, researchers find combination and sequential treatment with EGFR-TKIs, chemotherapy, and radiotherapy is beneficial.

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