Research

Efficacy and Safety of COX-2 Inhibitors for Advanced Non-small-cell Lung Cancer With Chemotherapy: A Meta-analysis

Efficacy and Safety of COX-2 Inhibitors for Advanced Non-small-cell Lung Cancer With Chemotherapy: A Meta-analysis

[OncoTargets and Therapy] This meta-analysis assesses the efficacy and safety profile of COX-2 inhibitors in patients with advanced non-small-cell lung cancer.

Vulvar Carcinoma: Dilemma, Debates, and Decisions

Vulvar Carcinoma: Dilemma, Debates, and Decisions

[Cancer Management and Research] A review of vulvar carcinoma and treatment options for patients with rare gynecologic cancer.

Comparative Study of Clinical Efficacy Using Three-dimensional and Two-dimensional Laparoscopies in the Treatment of Distal Gastric Cancer

Comparative Study of Clinical Efficacy Using Three-dimensional and Two-dimensional Laparoscopies in the Treatment of Distal Gastric Cancer

[OncoTargets and Therapy] This study investigated the safety and feasibility of 3D laparoscopic-assisted radical gastrectomy for distal advanced gastric cancer vs 2D laparoscopic surgery, results of this study have shown.

Radiotherapy for Esophageal Carcinoma: Dose, Response and Survival

[Cancer Management and Research] Radiation dose, fractionation strategies, and predictive factors of response to therapy in patients with esophageal carcinoma are reviewed to determine if more intense local therapy would lead to better outcomes and for which patients.

Novel β-chain-targeting approach for the treatment of lymphoma [PreClinical]

1. The β-chain constant region of the T cell receptor (TCR) was targeted to specifically eliminate a population of malignant T cells. 2. Engineered chimeric antigen receptor (CAR) T cells with specificity to the β-chain constant region successfully eradicated a significant proportion of malignant T cells in mice. Evidence Rating Level: 3 (Average) Study Rundown: []

Feasibility and Outcomes of Modified Enhanced Recovery After Surgery for Nursing Management of Aged Patients Undergoing Esophagectomy

Feasibility and Outcomes of Modified Enhanced Recovery After Surgery for Nursing Management of Aged Patients Undergoing Esophagectomy

[Journal of Thoracic Disease] A randomized study investigated whether an mERAS protocol could result in improved recovery of aged patients with esophageal cancer undergoing esophagectomy.

Comparison of Survival Outcomes Between Radical Hysterectomy and Definitive Radiochemotherapy in Stage IB1 and IIA1 Cervical Cancer

Comparison of Survival Outcomes Between Radical Hysterectomy and Definitive Radiochemotherapy in Stage IB1 and IIA1 Cervical Cancer

[Cancer Management and Research] A comparison study evaluated whether radical hysterectomy or radiochemotherapy provides superior survival outcomes for patients with stage IB1 or IIA1 cervical cancer.

Effect of Statins on Breast Cancer Recurrence and Mortality: A Review

Effect of Statins on Breast Cancer Recurrence and Mortality: A Review

[Breast Cancer: Targets and Therapy] Researchers present a review of study findings on the effect of statins on clinical outcomes for patients with breast cancer.

Blueberry Extract May Boost Efficacy of Radiotherapy for Cervical Cancer

Blueberry Extract May Boost Efficacy of Radiotherapy for Cervical Cancer

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In an effort to find alternatives to cisplatin as a radiation sensitizer, due to its dose-dependent toxicity and resistance, researchers are exploring food-based options such as blueberry extract.

Bridging the Gap in Genetic Cancer Research Data on Minority Populations

Bridging the Gap in Genetic Cancer Research Data on Minority Populations

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Investigators sought to determine why so few biospecimens were available for research from minority populations of women with breast cancer.

Male Occult Triple-negative Breast Cancer With Dermatomyositis: A Case Report and Review of the Literature

Male Occult Triple-negative Breast Cancer With Dermatomyositis: A Case Report and Review of the Literature

[OncoTargets and Therapy] In this case report, a patient with male breast cancer developed dermatomyositis.

Capecitabine and Oxaliplatin as First and Second Line Treatment for Locally Advanced and Metastatic Pancreatic Ductal Adenocarcinoma

Capecitabine and Oxaliplatin as First and Second Line Treatment for Locally Advanced and Metastatic Pancreatic Ductal Adenocarcinoma

[Journal of Gastrointestinal Oncology] This research evaluates the use of capecitabine and oxaliplatin (CAPOX) for first or second-line treatment of locally advanced or metastatic PDAC.

Clinical Aspects of Foot Health and Their Influence on Quality of Life Among Breast Cancer Survivors: A Case-control Study

Clinical Aspects of Foot Health and Their Influence on Quality of Life Among Breast Cancer Survivors: A Case-control Study

[Cancer Management and Research] Researchers determined the effect of breast cancer and its treatment on quality of life relative to foot health issues.

Optimal Therapy for Patients with Hepatocellular Carcinoma and Resistance or Intolerance to Sorafenib: Challenges and Solutions

Optimal Therapy for Patients with Hepatocellular Carcinoma and Resistance or Intolerance to Sorafenib: Challenges and Solutions

[Journal of Hepatocellular Carcinoma] This research examines systemic therapies that can be considered in patients with sorafenib refractory hepatocellular carcinoma.

Rare Cancer: An Underserved Oncology Area

Rare Cancer: An Underserved Oncology Area

As more rare cancers are identified, the need for rethinking approaches to research will become greater.

Nab-paclitaxel/carboplatin Induction in Squamous NSCLC: Longitudinal Quality of Life While on Chemotherapy

Nab-paclitaxel/carboplatin Induction in Squamous NSCLC: Longitudinal Quality of Life While on Chemotherapy

[Lung Cancer: Targets and Therapy] Researchers examine the affect of first-line nab-paclitaxel plus carboplatinon QoL for patients with advanced non-small cell lung cancer.

Practical Management of Adverse Events Associated With Cabozantinib Treatment in Patients With Renal-cell Carcinoma

Practical Management of Adverse Events Associated With Cabozantinib Treatment in Patients With Renal-cell Carcinoma

[OncoTargets and Therapy] This research reviews the management of the more common adverse events associated with cabozantinib treatment for patients with patients with advanced clear-cell renal-cell carcinoma.

A Structured Group Exercise Program for Patients With Metastatic Cancer Receiving Chemotherapy and CTNNB1 (β-catenin) as a Biomarker of Exercise Efficacy

A Structured Group Exercise Program for Patients With Metastatic Cancer Receiving Chemotherapy and CTNNB1 (β-catenin) as a Biomarker of Exercise Efficacy

[Cancer Management and Research] This research explores the feasibility of group exercise intervention using strength and aerobic training for patients with metastatic cancer undergoing chemotherapy.

Challenging the Standard of Care in Advanced Melanoma: Focus on Pembrolizumab

Challenging the Standard of Care in Advanced Melanoma: Focus on Pembrolizumab

[Cancer Management and Research] This study examines the advances that pembrolizumab has made in melanoma and upcoming research that may further improve melanoma treatment.

Is This the End of Cytotoxic Chemotherapy in Merkel Cell Carcinoma?

Is This the End of Cytotoxic Chemotherapy in Merkel Cell Carcinoma?

[OncoTargets and Therapy] A review of the role of chemotherapy in the treatment of Merkel cell carcinoma in view of the recent FDA approval of the PD-L1 antibody avelumab and limited and controversial data on the efficacy of chemotherapy in this disease.

Cardiac Magnetic Resonance Imaging in Oncology

Cardiac Magnetic Resonance Imaging in Oncology

[Cancer Control] This research examines cardio-oncology programs and their role in the multidisciplinary approach to cancer care.

Statins, Antihypercholesterolemic Drugs Show Potential as Anticancer Agents

Statins, Antihypercholesterolemic Drugs Show Potential as Anticancer Agents

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Study results demonstrate that statins have antitumor activity in various solid-tumor cancers and leukemia; however, experts offer these caveats on using them to treat cancer — at least for now.

Case Report of a KIT-mutated Melanoma Patient With an Excellent Response to Apatinib and Temozolomide Combination Therapy

Case Report of a KIT-mutated Melanoma Patient With an Excellent Response to Apatinib and Temozolomide Combination Therapy

[OncoTargets and Therapy] This article examines a case of metastatic melanoma in which the patient had an excellent response to apatinib/TMZ combination therapy with progression-free survival for more than one year.

New Class of Clinical Trial Enhances Research on Cancer Care Delivery

New Class of Clinical Trial Enhances Research on Cancer Care Delivery

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What is a CCDR clinical trial and how does it differ from clinical trials that test new drugs?

Osimertinib in the Treatment of Non-small Cell Lung Cancer: Design, Development and Place in Therapy

Osimertinib in the Treatment of Non-small Cell Lung Cancer: Design, Development and Place in Therapy

[Lung cancer: Targets and Therapy] This research examines clinical data from Phase I-III trials of osimertinib, discusses mechanisms of resistance to osimertinib, and provides an outlook for the use of osimertinib and novel therapeutic combinations to improve EGFR-mutated NSCLC outcomes.

High Rates of Adverse Events Lead to Earlier Dropouts in Phase 1 Cancer Trials

High Rates of Adverse Events Lead to Earlier Dropouts in Phase 1 Cancer Trials

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Phase 1 trials are used to determine the safety profiles of treatment regimens. In this retrospective review, investigators sought to understand the reasons participants in these studies drop out.

Complications and Management of Coagulation Disorders in Leukemia Patients

Complications and Management of Coagulation Disorders in Leukemia Patients

[Blood and Lymphatic Cancer: Targets and Therapy] Investigators conduct 4 case studies that illustrate a range of coagulation disorders that can develop in patients with leukemia to elucidate the rationale and process of specific treatment options.

Study Examines Role of MicroRNA in Tumor Growth

Study Examines Role of MicroRNA in Tumor Growth

A study examines the role of two hypoxia-responsive microRNAs, miR-25 and miR-93, in establishing an immunosuppressive tumour microenvironment.

Utilization and Trends in Palliative Therapy for Stage IV Pancreatic Adenocarcinoma Patients: A U.S. Population-based Study

Utilization and Trends in Palliative Therapy for Stage IV Pancreatic Adenocarcinoma Patients: A U.S. Population-based Study

[Journal of Gastrointestinal Oncology] This research examined patients who presented with metastatic pancreatic adenocarcinoma at diagnosis, and their patterns of palliative care utilization.

Dapsone, Danazol, Hydroxychloroquine Are Potential Second-line Options in ITP

Dapsone, Danazol, Hydroxychloroquine Are Potential Second-line Options in ITP

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A retrospective analysis of 28 studies determined that overall response rates for patients with ITP were similar treated with hydroxychloroquine, danazol, or dapsone in the second-line setting were similar.

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