Rectal Cancer
Guideline Recommendations Offer No OS Benefit for Younger Patients With Rectal Cancer
July 16, 2018A retrospective review of data from the National Cancer Data Base demonstrated that trends in rectal cancer may follow a pattern similar to that of colon cancer.
Colorectal Cancer Rates Increased Sharply Among Generation X and Millennials
March 20, 2017Incidence of colon and rectal cancers are increasing sharply in people younger than 50 years, the recommended age for initiating screening.
Short-Course Radiation With Delay to Surgery Improves Outcomes in Rectal Cancer
February 27, 2017Outcomes improved with short-course radiation and delay to surgery of 4 to 8 weeks.
Replacing Neoadjuvant CRT with Multiagent Chemo Not Recommended for Rectal Cancer
October 27, 2016In this study, the impact of advancements in surgical technique and systemic therapy for stage II and III rectal cancers was assessed via a comparison of outcomes after neoadjuvant chemoradiotherapy followed by definitive resection with those for neoadjuvant multiagent chemotherapy without radiation therapy.
Poor Compliance to Adjuvant Chemo Linked to Poorer Survival in Rectal Cancer
August 26, 2016Poor compliance to NCCN guidelines for adjuvant chemotherapy appears to be associated with poorer overall survival.
Substantial Increase in Use of Neoadjuvant Chemoradiotherapy for Rectal Cancer
April 14, 2016Use of neoadjuvant chemoradiotherapy (NACRT) before surgery among patients with rectal cancer has substantially increased over the past decade.
Nonoperative Management of Rectal Adenocarcinoma Examined
March 29, 2016Nearly 50% of patients with stage II/III rectal cancer achieve a complete clinical response via neoadjuvant chemoradiation.
Likelihood of Radiation Therapy for Rectal Cancer Affected by Travel Burden
March 22, 2016A new study indicates that patient travel distance to an appropriate treatment facility can impact whether radiation therapy is received.
Exercise During Neoadjuvant CRT Less Difficult Than Anticipated for Rectal Cancer
February 05, 2016Patients with rectal cancer reported aerobic exercise during neoadjuvant chemoradiotherapy to be more enjoyable and less difficult.
Reduced Toxicity, Similar Efficacy Achieved With Novel Regimen for Advanced Rectal Cancer
February 02, 2016No difference in local efficacy was found between two treatment regimens for colorectal cancer: short-course (5-day) radiation followed by consolidation chemotherapy before surgery and standard 5-week chemoradiation.
Optimal Time for Post-Chemo and -Radiotherapy Rectal Cancer Surgery Pinpointed
January 22, 2016Patients who had the procedure eight weeks after chemo and radiation therapy demonstrated the best survival rates.
Dietary Glutamic Acid Intake Linked With Lower CRC Risk
January 04, 2016Baseline dietary glutamic acid intake is associated with a lower risk for developing colorectal cancer, particularly in people who are not overweight.
Laparascopic Surgery Does Not Improve Outcomes Over Open Resection for Rectal Cancer
October 06, 2015Compared with open surgery, laparascopic surgery fails to improve outcomes for patients with stage 2 or 3 rectal cancer.
Resection of CRC Liver Metastases Linked With Higher Risk of Death Among Elderly Patients
September 10, 2015New study data associates the resection of colorectal cancer (CRC) liver metastases with greater risk of postoperative mortality among elderly patients.
Colonoscopy screening may reduce CRC-related mortality
July 14, 2015Patients with colorectal cancer that is detected during a colonoscopy screening are more likely to survive to longer than patients who are not diagnosed until they have symptoms.
Combination of mFOLFOX6 and Radiotherapy Yields Higher pCR in Rectal Cancer
May 31, 2015mFOLFOX6 administered concurrently with radiation therapy resulted in a higher pathological complete response in rectal cancer.
Surgery may not be necessary for some patients with rectal cancer
January 19, 2015Patients with rectal cancer that experienced a complete response had similar 4-year survival rates regardless of whether they had immediate surgery or pursued a watch-and-wait approach.
Wide variation exists in the quality and content of clinical cancer guidelines
December 16, 2014A review of top clinical guidelines for rectal cancer shows a variety of treatment recommendations.
Chemotherapy first may be helpful in rectal cancer
June 03, 2014A new phase II study finds that if chemotherapy is offered before radiation and surgery, more patients will be able to tolerate it and receive a full regimen of treatment.
Chemotherapy after radiation does not improve survival of rectal cancer
February 03, 2014Long-term results of an EORTC trial show that 5- fluorouracil (FU)-based adjuvant chemotherapy after preoperative chemoradiotherapy for patients with cT3-resectable T4 M0 rectal cancer does not improve survival or disease-free survival.
Regorafenib prolongs survival in face of GI cancers
December 13, 2012Persons with metastatic colorectal cancer or gastrointestinal stromal tumors may garner some survival benefit from regorafenib after standard treatments have failed.
Early end-of-life talks mean less aggressive care later
December 05, 2012Early end-of-life talks are associated with less aggressive care and greater use of hospice services when patients do reach their final days.
FDA Update - September/October 2012
October 26, 2012News from the FDA on bosutinib (Bosulif), ziv-aflibercept (Zaltrap), and everolimus oral suspension tablets (Afinitor Disperz).
New colonoscopy schedule mirrors prior advice
October 25, 2012Two of three main recommendations for colonoscopy surveillance are now supported by stronger evidence than they were in 2006.
Getting to 'the heart of the bad'
October 03, 2012I knew Sam's joking was not a sign of joy or happiness but his way of coping, maybe the only way he knew how.
Short-, long-course therapy comparable in T3 rectal cancer
September 27, 2012No significant differences in rates of local, distant recurrence; overall survival; or late toxicity.
FDA Update - July/August 2012
August 15, 2012News about pertuzumab injection (Perjeta); ondansetron (Zofran); carfilzomib (Kyprolis); Therascreen KRAS RGQ PCR Kit; Prostate Health Index (phi); and Prepopik
Laxative-free virtual colonoscopy can detect large polyps
July 05, 2012CT colonography can accurately detect adenomas 10 mm or larger in patients who did not undergo laxative-induced bowel cleansing before the procedure.
Colorectal risk defined for childhood cancer survivors
June 25, 2012Childhood cancer survivors may need earlier colorectal cancer screening, especially if abdominal radiation was part of their treatment.
Virtual colonoscopy is an accurate screen in seniors
June 05, 2012CT colonography accurately detects cancer and precancerous polyps in persons aged 65 years and older.
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