Drug Name:
QUELICIN Rx

Generic Name and Formulations:
Succinylcholine chloride 20mg/mL, 100mg/mL; soln for IM or IV inj.
Company:
Hospira
Therapeutic Use:
Indications for QUELICIN:
Adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Adult:
Individualize. Patients homozygous for atypical plasma cholinesterase gene: give test dose of 5–10mg (1mg/mL solution) by slow IV infusion. Short surgical (tracheal intubation): usual dose: 0.6mg/kg IV; range: 0.3–1.1mg/kg IV. Long surgical: (1–2mg/mL solution) by continuous infusion given at a rate of 2.5–4.3mg/min; alternatively by intermittent IV inj: initially 0.3–1.1mg/kg, followed by 0.04–0.07mg/kg. If suitable vein is inaccessible, may give by IM inj: up to 3–4mg/kg, max 150mg total dose.
Children:
See full labeling. Emergency tracheal intubation: infants and small children: 2mg/kg IV; older pediatric patients and adolescents: 1mg/kg IV. If suitable vein is inaccessible, may give by IM inj: up to 3–4mg/kg, max 150mg total dose.
Contraindications:
History of malignant hyperthermia or skeletal muscle myopathies. Acute phase of injury following major burns, multiple trauma, extensive denervation of skeletal muscle, or upper motor neuron injury.
Boxed Warning:
Risk of cardiac arrest from hyperkalemic rhabdomyolysis in children.
Warnings/Precautions:
To be administered only by those skilled in management of artificial respiration. Have intubation, adequate ventilation, oxygen therapy available. Should not be administered prior to induction of unconsciousness (unless emergency). Pretreatment with anticholinergic agents (eg, atropine) may reduce occurrence of bradyarrythmias. Caution in patients with reduced plasma cholinesterase activity in presence of gene abnormalities (eg, heterozygous or homozygous for atypical plasma cholinesterase gene), pregnancy, severe hepatic or renal disease, malignant tumors, infections, burns, anemia, heart disease, peptic ulcer, myxedema, or drugs affecting cholinesterase activity (see Interactions). Electrolyte abnormalities, digitalis toxicity, acute phase of injury (see Contraindications), chronic abdominal infection, subarachnoid hemorrhage, or conditions causing degeneration of central and peripheral nervous systems: increased risk of hyperkalemia. Hypokalemia or hypocalcemia (neuromuscular blockade may be prolonged). Risk of medication errors; confirm proper selection of intended product and ensure dose is clearly labeled/communicated. Monitor for possible transition into Phase II block (see full labeling). Glaucoma or eye injury. Bone fractures or muscle spasm. Children with skeletal muscle myopathy. Elderly. Pregnancy (Cat.C). Labor & delivery. Nursing mothers.
Pharmacological Class:
Skeletal muscle relaxant (depolarizing).
Interactions:
Potentiated by promazine, oxytocin, aprotinin, certain non-penicillin antibiotics, quinidine, β-adrenergic blockers, procainamide, lidocaine, trimethaphan, lithium carbonate, magnesium salts, quinine, chloroquine, diethyl ether, isoflurane, desflurane, metoclopramide, terbutaline, chronically administered oral contraceptives, glucocorticoids, certain MAOIs, organophosphates, ecothiophate, and certain antineoplastics. Antagonized by anticholinergics.
Adverse Reactions:
Respiratory depression or apnea (may be prolonged), cardiac arrest, malignant hyperthermia, arrhythmias, bradycardia, tachycardia, hyper- or hypotension, hyperkalemia, increased intraocular pressure, increased intragastric pressure, muscle fasciculation, jaw rigidity, post-op muscle pain, rhabdomyolysis with possible myoglobinuric acute renal failure, excessive salivation, rash, hypersensitivity reactions; children: acute rhabdomyolysis with hyperkalemia, ventricular dysrhythmias, cardiac arrest (rare).
How Supplied:
Single-dose vial 100mg/mL (10mL)—1 (preservative-free); Multi-dose vial 20mg/mL (10mL)—1
Sign Up for Free e-newsletters
ONA Articles
- FDA: Number of U.S. Women With Breast Implant-Caused Cancer Has Increased
- Immunotherapy for HER2-positive Breast Cancer: Recent Advances and Combination Therapeutic Approaches
- Nurse-Led vs Oncologist-Led Breast Cancer Follow-up Program: Early Feasibility Results of an Ongoing Study
- A Review of Clinical Outcomes in Patients With Early-Stage Burkitt Lymphoma
- Survey Demonstrates Relationship Between Symptom Burden, Medical Disability Leave Among Myeloproliferative Neoplasms
- Oncology Nurse Navigation Facilitates Timely Treatment of Pancreatic Cancer
- Substitute for Lidocaine
- Oncology Nurses Weigh In on Their Patient-Centered Communication Practices, Needs
- FDA: Number of U.S. Women With Breast Implant-Caused Cancer Has Increased
- Identifying the Needs of Multidisciplinary Team Treating Geriatics Cancer Patients
- Hypofractionated Radiotherapy for Prostate Cancer: The New ASTRO/ASCO/AUA Guideline
- Risk of Hospitalization Remains High for Survivors of Childhood Leukemia
- Sequence of Immunotherapy, Targeted Therapy, Radiation Therapy Influences Overall Survival in Melanoma Brain Metastases
- Survey Demonstrates Implicit Bias Toward Cervical Cancer Diagnoses Among Nurses, Women
- Use of Watchful Waiting Up for Low-Risk Localized Prostate Cancer
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
Bone Cancer | Regimens | Drugs |
Brain Cancer | Regimens | Drugs |
Breast Cancer | Regimens | Drugs |
Endocrine Cancer | Regimens | Drugs |
Gastrointestinal Cancer | Regimens | Drugs |
Genitourinary Cancer | Regimens | Drugs |
Gynecologic Cancer | Regimens | Drugs |
Head and Neck Cancer | Regimens | Drugs |
Hematologic Cancer | Regimens | Drugs |
Lung Cancer | Regimens | Drugs |
Other Cancers | Regimens | |
Rare Cancers | Regimens | |
Skin Cancer | Regimens | Drugs |