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PROSTIN VR PEDIATRIC
CHF and arrhythmias
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Drug Name:

PROSTIN VR PEDIATRIC Rx

Generic Name and Formulations:
Alprostadil 500mcg/mL; soln for IV infusion after dilution; contains dehydrated alcohol.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for PROSTIN VR PEDIATRIC:

Palliative therapy to maintain ductus arteriosus patency until corrective or palliative surgery can be performed in neonates with congenital heart defects and who depend on patent ductus for survival.

Adult:

Not applicable.

Children:

Use lowest effective dose for shortest duration. Give by continuous IV infusion into large vein (preferred) or through an umbilical artery catheter placed at the ductal opening. Initially 0.05–0.1mcg/kg/min. Reduce dose from 0.1 to 0.05 to 0.025 to 0.01mcg/kg/min after therapeutic response is achieved to provide lowest dose that maintains response. If inadequate response to 0.05mcg/kg/min; may increase up to 0.4mcg/kg/min.

Boxed Warning:

Apnea in neonates with congenital heart defects; use where ventilatory assistance is immediately available.

Warnings/Precautions:

Respiratory distress syndrome: not recommended. Bleeding disorders. Prolonged therapy (>120hrs): monitor for antral hyperplasia and gastric outlet obstruction. Monitor respiratory status, arterial pressure, blood oxygenation, BP, blood pH; decrease infusion rate if arterial pressure falls significantly. Neonates <2kg at birth.

Pharmacological Class:

Prostaglandin E1.

Interactions:

Caution with anticoagulants.

Adverse Reactions:

Apnea, fever, flushing, bradycardia, hypotension, tachycardia, seizures, diarrhea, sepsis, cortical proliferation of the long bones (long-term infusion).

How Supplied:

Ampules (1mL)—5

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