Pediatric Oncology

Long-term Impact of Retinoblastoma Therapy on Vision-Related Quality of Life

Long-term Impact of Retinoblastoma Therapy on Vision-Related Quality of Life

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Using the NEI-VFQ-25, researchers assessed vision-targeted health-related quality of life for survivors of retinoblastoma.

18F-FDG PET/CT Accurately Identifies Bone Marrow Involvement in Pediatric Hodgkin's Lymphoma

18F-FDG PET/CT Accurately Identifies Bone Marrow Involvement in Pediatric Hodgkin's Lymphoma

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Researchers conducted a retrospective study to assess 18F-FDG PET/CT vs bone marrow biopsy to detect bone marrow involvement among pediatric patients with Hodgkin lymphoma.

Oncology Clinicians Disagree on School Attendance for Children With Cancer 

Oncology Clinicians Disagree on School Attendance for Children With Cancer 

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A survey of oncology providers demonstrated a mix of opinions as to whether immunosuppressed children with cancer should attend school.

Palonosetron Noninferior to Ondansetron for Pediatric Chemotherapy-induced Vomiting

Palonosetron Noninferior to Ondansetron for Pediatric Chemotherapy-induced Vomiting

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In a prospective study, researchers sought to determine the noninferiority of palonosetron to ondansetron in pediatric patients with cancer receiving moderate or high emetogenic chemotherapy.

FDA Expands Nilotinib Indication to Include Pediatric Chronic Myeloid Leukemia

FDA Expands Nilotinib Indication to Include Pediatric Chronic Myeloid Leukemia

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Based on results of 2 prospective studies, the FDA approved the use of nilotinib in pediatric patients older than 1 year with newly diagnosed Ph+ CML-CP and those with TKI-intolerant or resistant disease.

Managing Chemo Brain in Pediatric Survivors of Childhood Cancer

Managing Chemo Brain in Pediatric Survivors of Childhood Cancer

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Reintegration to the general environment, particularly to school, can be challenging for survivors of childhood cancers. This review discusses how adverse effects such as chemo brain may present extra challenges for these patients and what can be done to ease patients' anxiety.

Higher Incidence, Risk of Some Cancers Seen After Childhood Pneumonia

Higher Incidence, Risk of Some Cancers Seen After Childhood Pneumonia

Children who were hospitalized with pneumonia may be at higher risk of certain cancer types.

Tisagenlecleucel Produces Durable Remissions in Pediatric, Young Adult B-cell ALL

Tisagenlecleucel Produces Durable Remissions in Pediatric, Young Adult B-cell ALL

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A previous single-site trial showed that patients with R/R B-cell ALL treated with tisagenlecleucel achieved high complete remission rates. In this study, investigators report on results after the scope of the study was expanded.

Specialized Pediatric Palliative Care Reduces High-Intensity Care at End of Life

Specialized Pediatric Palliative Care Reduces High-Intensity Care at End of Life

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A retrospective study of data from POGONIS evaluated the effectiveness of specialized pediatric palliative care vs general palliative care or no palliative care in pediatric patients with cancer at the end of life.

Survey Reveals Opinions, Barriers Regarding Medical Marijuana Use in Children

Survey Reveals Opinions, Barriers Regarding Medical Marijuana Use in Children

A survey of pediatric oncology providers including physicians, nurses, and social workers reveals their willingness to consider medical marijuana for children with cancer, as well as their reasons against its use in these patients.

History of Headache, Vomiting, Seizures Associated With Pediatric Brain Cancer

History of Headache, Vomiting, Seizures Associated With Pediatric Brain Cancer

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Research pinpointed clinical factors, such as headache, that may be associated with pediatric brain neoplasms.

Fosaprepitant Improves Standard Antiemetic Therapy in Pediatric Patients

Fosaprepitant Improves Standard Antiemetic Therapy in Pediatric Patients

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Data presented at ASH 2017 illustrates the effectiveness of 2 prophylactic antiemetic regimens in pediatric patients receiving moderately or highly emetogenic chemotherapy.

4R+3Dex Regimen May Lead to Durable Complete Response in Pediatric Chronic ITP

4R+3Dex Regimen May Lead to Durable Complete Response in Pediatric Chronic ITP

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Young patients with chronic ITP may experience relapse within 5 years of completing therapy. In this study, investigators sought to determine if the 4R+3Dex regimen for chronic ITP would improve response rates in pediatric patients with the disease.

Reduced Delayed Intensification Impacts Risk of Pediatric ALL Relapse

Reduced Delayed Intensification Impacts Risk of Pediatric ALL Relapse

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Improved survival in pediatric patients with standard-risk ALL has shifted the focus toward reducing treatment burden and toxicity; therefore, researchers sought to determine the effects of reduced DI chemotherapy on relapse and survival.

Dasatinib Granted Regular FDA Approval for Ph+ CML in Pediatric Patients

Dasatinib Granted Regular FDA Approval for Ph+ CML in Pediatric Patients

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US FDA approval of dasatinib is extended to pediatric patients with Ph+ CML based on data from 2 open-label, nonrandomized trials involving 97 patients.

Current, Emerging Systemic and Targeted Therapies for Pediatric Leukemia: A Review

Current, Emerging Systemic and Targeted Therapies for Pediatric Leukemia: A Review

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In this review, investigators discuss current and emerging treatments for acute lymphocytic leukemia and acute myeloid leukemia in pediatric patients.

Cancer Risk Not Increased by Childhood Exposure to Diagnostic Radiation

Cancer Risk Not Increased by Childhood Exposure to Diagnostic Radiation

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Risk of developing cancer as a result of childhood exposure to medical imaging radiation is not increased in children or adults, a new study reports.

Screening Recommendations for Children with Common Cancer Predisposition Syndromes

Screening Recommendations for Children with Common Cancer Predisposition Syndromes

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The Pediatric Cancer Working Group of the AACR released its first consensus screening guidelines for children with common cancer predisposition syndromes.

Self-Reports on Adverse Effects From Younger Patients Are Reliable, Accurate

Self-Reports on Adverse Effects From Younger Patients Are Reliable, Accurate

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Children and adolescent patients with cancer are able to accurately report subjective adverse events (AEs) they experience during their cancer treatment, and they are willing to do so.

Checkpoint Inhibitors Appear Safe for Pediatric Cancer Patients

Checkpoint Inhibitors Appear Safe for Pediatric Cancer Patients

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The medications so far show little efficacy in children with cancer, but new studies may provide clues to how to change this, pediatric oncologist says.

Pediatric Acute Lymphoblastic Leukemia Extramedullary Relapse Responds to CAR-T

Pediatric Acute Lymphoblastic Leukemia Extramedullary Relapse Responds to CAR-T

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Children with extramedullary relapse of CD19+ acute lymphoblastic leukemia experienced a potent and durable response to the immunotherapy.

Videos, Movies Eliminates Need for Anesthesia During Pediatric Radiation Therapy

Videos, Movies Eliminates Need for Anesthesia During Pediatric Radiation Therapy

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Pediatric patients are better able to tolerate radiation therapy without anesthesia when video movies are projected on the inside of the machine during treatment.

Oncolytic HSV-1 Promising in Refractory Incurable Non-CNS Solid Tumors in Pediatric Patients

Oncolytic HSV-1 Promising in Refractory Incurable Non-CNS Solid Tumors in Pediatric Patients

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Oncolytic variants of the HSV-1 have successfully treated melanoma, glioma, and other cancers in adults; in this study, researchers test the effectiveness of an oncolytic HSV-1 in pediatric patients.

Social Functioning Scores for Young Cancer Survivors Remain Lower Than Their Peers

Social Functioning Scores for Young Cancer Survivors Remain Lower Than Their Peers

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AYAs continue to report lower social functioning scores than their peers 2 years after diagnosis.

Dance/Movement Therapy: A Unique and Enjoyable Approach to Support Children with Cancer

Dance/Movement Therapy: A Unique and Enjoyable Approach to Support Children with Cancer

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Dr Lori Baudino, a clinical psychologist and dance/movement therapist, discusses a program that helps children with cancer cope with their disease and treatment, and learn to be children again.

Pediatric Papillary Thyroid Cancer: Current Management Challenges

Pediatric Papillary Thyroid Cancer: Current Management Challenges

[OncoTargets and Therapy] This research presents an overview of patient and disease management in pediatric pediatric papillary thyroid (PTC) patients.

New Oral Therapy Shows Promise Against Neurofibromatosis Type 1-Related Plexiform Neurofibromatomas in Children

New Oral Therapy Shows Promise Against Neurofibromatosis Type 1-Related Plexiform Neurofibromatomas in Children

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In this clinical trial, researchers determined the safety and efficacy of selumetinib, a selective MEK inhibitor, in children with NF1-related neurofibromas.

Pediatric Patients Continue to Experience High-Intensity EOL Care

Pediatric Patients Continue to Experience High-Intensity EOL Care

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Studies of end-of-life (EOL) care for pediatric patients have been limited to single institutions or lacked detailed clinical data. Therefore, researchers conducted a retrospective cohort study to examine predictor of, and trends in, high-intensity EOL care in this patient population.

Drug Prevents Heart Damage in Pediatric Patients Receiving Chemotherapy

Drug Prevents Heart Damage in Pediatric Patients Receiving Chemotherapy

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Dexrazoxane has cardioprotective properties that can prevent long-term cardiotoxicity in pediatric patients receiving chemotherapy, according to a review of the medical literature on cardiotoxic effects of anthracycline treatment.

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