Generic Name and Formulations:
Semaglutide 2mg/1.5mL (1.34mg/mL); per pen injector; soln for SC inj.
RECENT UPDATESMonograph added.
Indications for OZEMPIC:
As adjunct to diet and exercise, to improve glycemic control in type 2 diabetes mellitus (T2DM).
Limitations Of use:
Not recommended as first-line therapy for patients inadequately controlled on diet and exercise. Not studied with a history of pancreatitis. Not a substitute for insulin. Not for treating type 1 diabetes or diabetic ketoacidosis.
Give by SC inj in abdomen, thigh, or upper arm; rotate inj sites. Initially 0.25mg once weekly for 4 weeks, then 0.5mg once weekly for at least 4 weeks; if additional control needed, may increase to 1mg once weekly (max).
<18yrs: not established.
History (personal or family) of medullary thyroid carcinoma. Multiple endocrine neoplasia syndrome type 2.
Risk of thyroid C-cell tumors; inform patients of potential risk and symptoms. History of pancreatitis; consider other antidiabetics. Monitor for pancreatitis; discontinue if suspected; do not restart if confirmed. History of diabetic retinopathy; monitor for progression. Do not reuse or share pens or needles between patients. Monitor renal function when initiating or escalating dose. History of anaphylaxis or angioedema with another GLP-1 agonist. Pregnancy. Females of reproductive potential: discontinue ≥2 months prior to planned pregnancy. Nursing mothers.
Concomitant insulin; administer as separate injections not adjacent to each other. Increased risk of hypoglycemia with concomitant insulin secretagogues (eg, sulfonylureas) or insulin; may need lower dose of these. May affect absorption of concomitant oral drugs (delayed gastric emptying); caution.
Glucagon-like peptide-1 (GLP-1) receptor agonist.
Nausea, vomiting, diarrhea, abdominal pain, constipation; rare: pancreatitis, hypersensitivity reactions (discontinue if occur).
Single-patient-use pre-filled pen (0.25mg or 0.5mg per inj)—1; (1mg per inj)—2
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