Fathers Can Pass Inherited Ovarian Cancer Risk to Daughters

Share this content:
Research on inherited cancer risk involved testing of DNA samples from participating women with ovarian cancer.
Research on inherited cancer risk involved testing of DNA samples from participating women with ovarian cancer.

Ovarian cancer risk is elevated in women with sisters or paternal grandmothers who have been affected, according to a study published in PLoS Genetics.

Kevin H Eng, PhD, of the Department of Biostatistics and Bioinformatics at Roswell Park Cancer Institute in Buffalo, NY, and colleagues hypothesized that ovarian cancer may be X-linked and the associated genes may be passed from the paternal grandmother though the father's inherited genetic material.

The investigators conducted a series of tests using DNA from 186 women with ovarian cancer who were registered in the Familial Ovarian Cancer Registry at Roswell Park Cancer Institute via germline X-chromosome sequencing.

They reported an earlier age-of-onset in paternal grandmothers compared with maternal grandmothers (hazard ratio [HR], 1.59), though both were mutually exclusive from BRCA1 and BRCA2.

To confirm X-linked association, the researchers measured the correlation between prostate cancer in men and ovarian cancer in their mothers and daughters (odds ratio [OR], 2.34). Mothers who did not have ovarian cancer but had affected daughters had significantly more female than male offspring (OR, 1.96).

“We have presented evidence that there may exist an X-linked model of transmission of an ovarian cancer susceptibility gene,” the authors wrote.

“Future studies are warranted to confirm the identity and function of the X-linked gene that contributes to familiar transmission of ovarian cancer.”


Eng KH, Szender JB, Etter JL, et al. Paternal lineage early onset hereditary ovarian cancers: A familial ovarian cancer registry study. PLoS Genetics. 2018 Feb 15. doi:10.1371/journal.pgen.1007194

You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs