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Ofloxacin Tablets
Bacterial infections
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Drug Name:

Ofloxacin Tablets Rx

Generic Name and Formulations:
Ofloxacin 200mg, 300mg, 400mg; tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Ofloxacin Tablets:

Susceptible infections including acute bacterial exacerbation of chronic bronchitis (ABECB), community-acquired pneumonia, acute pelvic inflammatory disease (PID), acute, uncomplicated cervical and urethral gonorrhea, urethritis, cervicitis, uncomplicated cystitis, uncomplicated skin and skin structure, complicated UTIs, prostatitis. For ABECB and uncomplicated cystitis: reserve for those who have no alternative treatment options.

Adult:

≥18yrs: Take with full glass water. Bronchitis, pneumonia, uncomplicated skin and skin structure: 400mg every 12 hours for 10 days. Urethritis, cervicitis: 300mg every 12 hours for 7 days. Gonorrhea: 400mg once as a single dose. PID: 400mg every 12 hours for 10–14 days. Uncomplicated cystitis due to E. coli or K. pneumoniae: 200mg every 12 hrs for 3 days. Other uncomplicated cystitis: 200mg every 12 hrs for 7 days. Complicated UTIs: 200mg every 12 hrs for 10 days. Prostatitis due to E. coli: 300mg every 12 hours for 6 weeks. Severe hepatic impairment: max 400mg/day. Renal impairment: CrCl 20–50mL/min: give normal dose (loading dose) and increase dosing interval to 24 hours. CrCl <20mL/min: give normal dose once (loading dose) then ½ normal dose and increase dosing interval to 24 hours.

Children:

<18yrs: not established.

Warnings/Precautions:

Increased risk of disabling and potentially irreversible adverse reactions (including tendinitis/tendon rupture [esp. in patients >60yrs, or those with kidney, heart or lung transplants], peripheral neuropathy, or CNS/psychiatric effects); discontinue immediately if signs/symptoms occur. CNS disorders (eg, cerebral arteriosclerosis, epilepsy) that increase seizure risk. History of myasthenia gravis; avoid. History of QT prolongation, ventricular arrhythmias, proarrhythmic conditions (eg, bradycardia, acute myocardial ischemia), hypokalemia; avoid. Discontinue at 1st sign of skin rash, jaundice, any other hypersensitivity, hepatitis, or photosensitivity. Monitor blood glucose in diabetic patients; discontinue if hypoglycemia occurs. Renal or hepatic impairment. Maintain adequate hydration. May mask symptoms of syphilis; test for syphilis before treating gonorrhea then follow-up after 3mos. Monitor blood, renal, and hepatic function in prolonged use. Avoid excessive sun or UV light. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacological Class:

Quinolone.

Interactions:

Avoid drugs that prolong QT interval (eg, Class IA or Class III antiarrhythmics). Take at least 2hrs before or 2hrs after magnesium- or aluminum-containing antacids, sucralfate, metal cations, multivitamins containing zinc or iron, or didanosine (buffered forms). Increased risk of tendinitis/tendon rupture with corticosteroids. Severe hypoglycemia with antidiabetics (eg, insulin, glyburide); monitor. Increased seizure risk with concomitant NSAIDs. May be potentiated by probenecid. May potentiate cyclosporine, theophylline, warfarin, other drugs metabolized by CYP450; monitor. May cause false (+) urine screening results for opiates using commercially available immunoassays.

Adverse Reactions:

Nausea, headache, insomnia, female genital pruritus, dizziness, vaginitis, diarrhea, vomiting; tendinitis/tendon rupture, peripheral neuropathy, CNS effects, hypersensitivity reactions, hepatotoxicity, C. difficile-associated diarrhea, torsades de pointes, dysglycemia, phototoxicity.

Note:

Formerly known under the brand name Floxin.

How Supplied:

Contact supplier

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