Myeloproliferative Neoplasms News & Features
Metformin Plus Ruxolitinib: A Potential Therapeutic Alternative for Myeloproliferative Neoplasms
Researchers investigated the antileukemic activity of metformin and ruxolitinib alone and in combination in patients with myeloproliferative neoplasms.
Risk Factors for Arterial, Venous Thrombosis Differ in Polycythemia Vera
Researchers assessed outcomes for 587 patients with PV to determine the risk factors most likely to predict arterial or venous thrombosis in this patient population.
High-Dose Dexamethasone Effective With Less Adverse Effects in ITP vs Corticosteroids
In this randomized trial, investigators sought to determine the effectiveness of high-dose dexamethasone vs conventional prednisone therapy in treatment-naïve patients with ITP. Results were presented at ASH 2017.
Ruxolitinib Beneficial in Hydroxyurea Resistant/Intolerant Polycythemia Vera
Data presented at ASH 2017 confirm that ruxolitinib improves hematocrit control, hematologic remission, and reduction in spleen size in some patients with polycythemia vera who fail hydroxyurea.
MDS, AML a Risk With PARP Inhibitors in BRCA Mutation Carriers
What is the concern behind PARP inhibitors and leukemia?
Ruxolitinib Not Superior to Second-line Treatments for Essential Thrombocythemia
A phase 2 study compared ruxolitinib with best-available therapy as second-line treatment for patients with high-risk essential thrombocythemia or polycythemia vera who became intolerant of first-line therapy.
Complications and Management of Coagulation Disorders in Leukemia Patients
[Blood and Lymphatic Cancer: Targets and Therapy] Investigators conduct 4 case studies that illustrate a range of coagulation disorders that can develop in patients with leukemia to elucidate the rationale and process of specific treatment options.
A Case of Newly Diagnosed PCV After Relapse TTP Complicated by Undiagnosed RA
This case of a 63-year-old African American male with a complicated history illustrates the need for a comprehensive risk assessment of thrombosis in patients with primary polycythemia vera, especially those with concomitant conditions that predispose to thrombosis.
A Patient's Guide to Managing Symptoms of Polycythemia Vera (Fact Sheet)
This fact sheet reviews common symptoms associated with polycythemia vera (PV) and how a patient may address them, along with an overview of more serious symptoms that require medical attention.
Arthritis Medication Shows Potential in the Treatment of Polycythemia Vera
Methotrexate, a medication used commonly in the treatment of arthritis, shows promise as a treatment for polycythemia vera, a blood cancer classified as a myeloproliferative neoplasm.
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