MESNEX INJECTION Rx

Indications for MESNEX INJECTION:

Prophylactic agent in reducing the incidence of ifosfamide-induced hemorrhagic cystitis.

Adult:

See literature. IV Schedule: Give as IV bolus injection in a dosage equal to 20% of the ifosfamide dose at the time of ifosfamide administration and 4 and 8 hours after each dose of ifosfamide; total daily dose is 60% the ifosfamide dose. IV and oral dosing: Give as IV bolus injection in a dosage equal to 20% of the ifosfamide dose at the time of ifosfamide administration, followed by the tablets given orally in a dosage equal to 40% of the ifosfamide dose 2 and 6 hours after each dose of ifosfamide; total daily dose is 100% of the ifosfamide dose. Repeat schedule on each day ifosfamide is given. If vomiting occurs within 2hrs of oral mesna, repeat dose or give IV mesna.

Children:

Not recommended.

Contraindications:

Hypersensitivity to thiol compounds.

Warnings/Precautions:

Monitor morning specimen of urine for the presence of hematuria each day prior to ifosfamide therapy; consider dose reduction or discontinue if hematuria occurs. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.

See Also:

MESNEX

Pharmacological Class:

Cytoprotective agent.

Adverse Reactions:

GI upset, fever, anorexia, flatulence, constipation, rhinitis, rigors, back pain, rash, conjunctivitis, arthralgia, headache, inj site reactions, flushing, dizziness, pharyngitis, hyperaesthesia, flu-like symptoms, coughing; hypersensitivity reactions.

Note:

Patients taking mesna should drink at least a quart of liquid a day.

How Supplied:

Tabs—10; Multidose vials—1, 10