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MEPRON
Fungal infections
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Drug Name:

MEPRON Rx

Generic Name and Formulations:
Atovaquone 750mg/5mL; oral susp; citrus flavor.

Company:
GlaxoSmithKline

Therapeutic Use:

Indications for MEPRON:

Treatment of mild-to-moderate Pneumocystis jirovecii pneumonia (PCP) in patients intolerant to trimethoprim/sulfamethoxazole (TMP/SMX). Prevention of PCP in patients intolerant to TMP/SMX.

Limitations Of use:

Treatment of more severe PCP has not been studied. Mepron's efficacy has not been studied in those who are failing therapy with TMP/SMX.

Adult:

Take with food. ≥13yrs: Treatment: 750mg twice daily for 21 days. Prophylaxis: 1500mg once daily.

Children:

<13yrs: not established.

Warnings/Precautions:

GI disorders or inability to take with food. Monitor in severe hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers.

Pharmacological Class:

Naphthoquinone.

Interactions:

Concomitant rifampin or rifabutin: not recommended. Antagonized by tetracycline; caution and monitor if use is needed. May be antagonized by metoclopramide (use only if other antiemetics are not available). Antagonizes indinavir; caution and monitor if use is needed.

Adverse Reactions:

Diarrhea, rash, headache, nausea, fever, rhinitis, vomiting, sweating, flu syndrome, sinusitis, pruritus, insomnia, depression, myalgia.

How Supplied:

Susp—210mL

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