Melanoma Cancer section

Melanoma News & Features

Quick Take: Phase Ib/II Study of Pembrolizumab and Pegylated Interferon Alfa-2b in Advanced Melanoma

Programmed death-1 (PD-1) inhibitors have shown efficacy in the treatment of melanoma. Pre-existing CD8+ T-cell infiltrate and interferon (IFN) gene signature has been shown to correlate with response to PD-1 blockade. As such, the receipt of combination therapy with interferon (IFN) may enhance anti-tumor effects. In this open-label phase Ib/II trial, investigators treated 43 patients []

AAD Releases New Guidelines for the Treatment of Cutaneous Melanoma

AAD Releases New Guidelines for the Treatment of Cutaneous Melanoma

Guidelines recommend surgical excision as primary treatment modality, and emphasize individualized care.

CheckMate 067 Gives Nivolumab Alone, With Ipilimumab the Nod in Advanced Melanoma

CheckMate 067 Gives Nivolumab Alone, With Ipilimumab the Nod in Advanced Melanoma

Survival and progression-free survival were better with nivolumab alone or with ipilimumab vs ipilimumab alone for stage III or IV melanoma with known BRAFV600 mutation, according to results of this randomized study.

Novel Immunotherapy May Increase Survival in Melanoma Brain Metastases

Novel Immunotherapy May Increase Survival in Melanoma Brain Metastases

Researchers used data from the National Cancer Database to evaluate the overall survival of patients who presented with cutaneous MBM from 2010 to 2015.

SD-101 May Enhance the Effectiveness of Immunotherapy in Melanoma

SD-101 May Enhance the Effectiveness of Immunotherapy in Melanoma

In this phase 1b study, researchers evaluated the efficacy of immunotherapy with pembrolizumab to treat advanced melanoma.

Red Hair Variants of MC1R Influence Melanoma Risk Differently in Men, Women

Red Hair Variants of MC1R Influence Melanoma Risk Differently in Men, Women

Multivariate logistic regression analyses were utilized by researchers to evaluate the effect of MC1R and melanoma risk in men vs women.

Assessing Direct Costs of Treatment-Related Adverse Events in Advanced Melanoma

Assessing Direct Costs of Treatment-Related Adverse Events in Advanced Melanoma

In a systematic review, researchers explored the financial burden of treating grade 3 to 4 adverse events associated with melanoma and its treatment.

Is Radioimmunotherapy a Path Forward for Melanoma?

Is Radioimmunotherapy a Path Forward for Melanoma?

Recent research implicates patients' immune cells appear to stimulate radiation abscopal effects, raising the possibility that combining radiotherapy and immunotherapy could yield previously-untapped treatment synergies to improve tumor control.

Frequency of Tanning, Risk for Melanoma Higher in Gym Tanners

Frequency of Tanning, Risk for Melanoma Higher in Gym Tanners

The use of tanning beds and/or booths and their availability in gyms may increase the frequency of indoor tanning for physically active adults, a combination that further exacerbates their risk for melanoma.

Skinder App Helps Develop Skills in Intuitive Diagnosis of Melanoma

Skinder App Helps Develop Skills in Intuitive Diagnosis of Melanoma

Medical students participating in this study were randomly assigned to either a rule-based or application group.

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