Ovarian Cancer Includes More Than One Kind of Malignancy

Ovarian Cancer Includes More Than One Kind of Malignancy

Ovarian cancer isn't a single disease, but rather a number of different malignancies, and better understanding is needed to improve prevention and treatment according to a U.S. panel.

Indeterminate melanoma cases reduced by three-quarters by diagnostic test


Malignant melanoma was differentiated from benign skin lesions with high accuracy in a pivotal clinical utility study of the Myriad myPath Melanoma test.

Blood-protein set distinguishes malignant and benign lung tumors


A combination of blood proteins was able to differentiate between benign lung nodules and early-stage lung cancer with 90% probability, thereby providing a diagnostic tool to avoid invasive biopsy on benign nodules.

Potential new target to treat malignant pleural mesothelioma


Malignant mesothelioma is a rare asbestos-associated malignancy with limited therapeutic options. But recent research has concluded that Eprin (EPH) B2 seems to play an important role in malignant pleural mesothelioma cell lines and tumors.

Melanoma uses weak immune cells to its advantage

Melanoma tumors create conditions that attract immunoglobulin G4 (IgG4), the B-cell antibody class least effective in activating immune response.

Suppressed protein halted melanoma metastasis

Inhibiting one protein eliminated metastasis of melanoma in lab studies, a finding that could lead to targeted therapies for a range of cancers.

Study shows cause of and potential cure for aggressive leukemia

Excessive levels of interleukin-15 initiate large granular lymphocyte (LGL) leukemia, but also represent a promising therapeutic target.

Cell stiffness may predict ovarian cancer metastasis


For ovarian cancer and perhaps other cancer types, cell stiffness may be a useful biomarker to measure relative metastatic potential.

Measuring water in breast tissue may prevent unnecessary biopsies

Assessing how water moves through breast tissue may reduce false-positive findings among women undergoing dynamic contrast-enhanced MRI.

Use more preop needle biopsy in breast cancer, urge researchers

The quality of breast cancer surgery improved when percutaneous needle biopsy was performed preoperatively.

Dual drug therapy delayed treatment resistance in melanoma

Two drugs under FDA evaluation slowed treatment resistance in persons with metastatic malignant melanoma positive for the BRAF protein.

Breath test can indicate lung cancer

An analysis of breath samples from patients with pulmonary nodules distinguished benign from malignant growths in a recent study.

Short-term fasting enhances brain tumor treatment

A controlled fasting period lasting no more than 48 hours improved the effectiveness of chemotherapy and radiation therapy in mice with gliomas.

Multiple tumors worsen glioblastoma prognosis

Persons with more than one glioblastoma tumor upon diagnosis experience significantly worse survival than do patients with a solitary lesion.

Stem-like cells help glioblastoma defy treatment

A slower-growing set of glioblastoma multiforme cells appears to be the source of the brain cancer's recurrence following standard drug therapy.

Only a few gene mutations important in leukemia

Most of the hundreds of mutations found in acute myeloid leukemia (AML) genomes occur randomly as part of the aging process, unrelated to cancer.

Multidrug approach fights resistance

Multidrug approach fights resistance

Research results suggest that of the billions of cancer cells that exist in a patient, only about one in a million is resistant to drugs using targeted therapy.

Ridding cells of EYA3 boosts chemotherapy response in Ewing sarcoma

Scientists have identified a protein that makes some children and teenagers afflicted with Ewing sarcoma more resistant to chemotherapy.

Liposuction helps manage lymphedema in head and neck cancer


In patients with a previous head and neck cancer, liposuction is a well-tolerated surgical treatment for persistent submental lymphedema.

Experimental drug shrinks melanoma tumors

Dabrafenib, which targets a genetic mutation that is active in half of melanoma cases, substantially and safely shrank metastatic tumors.

FDA Update: May/June 2012

Drug Safety Communication on lenalidomide (Revlimid); FDA approval for pazopanib (Votrient)

BI-RADS and breast MRI useful in predicting malignancy

The Breast Imaging Reporting and Data System (BI-RADS) terminology is useful in predicting malignancy in breast lesions detected with MRI.

Gene anomaly can predict behavior of prostate cancer

A specific genomic abnormality found in either benign or malignant prostate tissues is predictive of the clinical outcome of prostate cancer.

Heart risks of cancer drugs underestimated

The system for monitoring adverse events in oncology clinical trials is in urgent need of reform, say the authors of a recent commentary.

Some pregnancies can continue despite cervical, ovarian cancers

The current trend is to preserve pregnancy in women diagnosed with cervical or ovarian cancer whenever feasible, according to a recent review.

Side effects of certain cancer drugs may be fatal


Sorafenib, sunitinib, and pazopanib have been found to carry a heightened risk of fatal complications, but the incidence remains low overall.

Make genetic testing part of retinoblastoma care

Genetic evaluations by a multidisciplinary health team improved risk prediction for children with retinoblastoma and their relatives, and prevented overuse of clinical screening tests.

Older blood cancer patients may benefit from cell transplant regimen

A regimen using minimal-intensity radiation therapy before bone marrow or stem cell transplantation may work for older patients who cannot tolerate stronger pretransplant treatment.

Cancer risk doubles for organ-transplant recipients

Compared with the general population, recipients of a kidney, liver, heart, or lung transplant have twice as great a risk for diverse infection-related and unrelated cancers.

SQUID may improve breast cancer detection

An emerging application known as magnetic relaxometry demonstrated 100 times greater sensitivity than mammography imaging in identifying breast tumors.

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